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Progranulin and Central Nervous System Disorders

Editors: Hara, H., Hosokawa, M., Nakamura, S., Shimohata, T., Nishihara, M. (Eds.)

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  • Reviews the effects and mechanisms of action of progranulin
  • Explores the value of progranulin as a therapeutic target
  • Discusses emerging treatment approaches for CNS disorders
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eBook 91,62 €
price for Spain (gross)
  • ISBN 978-981-13-6186-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-981-13-6185-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.


About the authors

Hideaki Hara, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan

Masato Hosokawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Japan

Shinsuke Nakamura, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan

Takayoshi Shimohata, Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Japan  

Masugi Nishihara, Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan


Table of contents (11 chapters)

Table of contents (11 chapters)

Buy this book

eBook 91,62 €
price for Spain (gross)
  • ISBN 978-981-13-6186-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-981-13-6185-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Progranulin and Central Nervous System Disorders
Editors
  • Hideaki Hara
  • Masato Hosokawa
  • Shinsuke Nakamura
  • Takayoshi Shimohata
  • Masugi Nishihara
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-6186-9
DOI
10.1007/978-981-13-6186-9
Hardcover ISBN
978-981-13-6185-2
Edition Number
1
Number of Pages
VII, 183
Number of Illustrations
24 b/w illustrations, 13 illustrations in colour
Topics