Progranulin and Central Nervous System Disorders
Editors: Hara, H., Hosokawa, M., Nakamura, S., Shimohata, T., Nishihara, M. (Eds.)
Free Preview- Reviews the effects and mechanisms of action of progranulin
- Explores the value of progranulin as a therapeutic target
- Discusses emerging treatment approaches for CNS disorders
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- About this book
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This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.
- About the authors
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Hideaki Hara, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan
Masato Hosokawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Japan
Shinsuke Nakamura, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan
Takayoshi Shimohata, Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Japan
Masugi Nishihara, Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
- Table of contents (11 chapters)
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Molecular and Functional Properties of Progranulin
Pages 1-17
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Progranulin as a Potential Biomarker of Central Nervous System Disease
Pages 19-34
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Progranulin and Frontotemporal Lobar Degeneration
Pages 35-69
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PGRN and Neurodegenerative Diseases Other Than FTLD
Pages 71-84
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Progranulin Regulations of Lysosomal Homeostasis and Its Involvement in Neurodegenerative Diseases
Pages 85-103
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Table of contents (11 chapters)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Progranulin and Central Nervous System Disorders
- Editors
-
- Hideaki Hara
- Masato Hosokawa
- Shinsuke Nakamura
- Takayoshi Shimohata
- Masugi Nishihara
- Copyright
- 2019
- Publisher
- Springer Singapore
- Copyright Holder
- Springer Nature Singapore Pte Ltd.
- eBook ISBN
- 978-981-13-6186-9
- DOI
- 10.1007/978-981-13-6186-9
- Hardcover ISBN
- 978-981-13-6185-2
- Softcover ISBN
- 978-981-13-6188-3
- Edition Number
- 1
- Number of Pages
- VII, 183
- Number of Illustrations
- 24 b/w illustrations, 13 illustrations in colour
- Topics
