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Advances in Experimental Medicine and Biology

Smooth Muscle Spontaneous Activity

Physiological and Pathological Modulation

Editors: Hashitani, Hikaru, Lang, Richard J. (Eds.)

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  • Detailed, up-to-date information on smooth muscle function
  • Systematically organized by body systems and organs
  • Explanation of commonalities and differences between organs
  • Clarification of the role of smooth muscle in disease
  • Exploration of contractile mechanisms as therapeutic targets
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eBook 130,89 €
price for Spain (gross)
  • ISBN 978-981-13-5895-1
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Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-981-13-5894-4
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  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This book presents the commonality and heterogeneity of the mechanisms underlying smooth muscle spontaneous activity in various smooth muscle organs and in addition discusses their malfunctions in disease and their potential as novel therapeutic targets. To facilitate understanding, the volume is divided into five parts and covers 16 organs: airways, gastrointestinal tract (phasic muscle, tonic muscle), renal pelvis, ureter, urinary bladder, urethra, corporal tissue, prostate, uterus, oviducts, seminal vesicle, artery, vein, microvasculature, and lymphatic vessels. This structure will help readers to comprehend the most up-to-date information on the similarities and differences in the contractile mechanisms driving various smooth muscles as well as their potential manipulations in particular visceral organ pathologies. The vast advancements in gene, electrical recording, and imaging technologies in this field are also discussed, with review of past achievements and consideration of likely future developments. This book will be of worldwide interest to clinicians, students, and researchers alike. 

About the authors

Hikaru Hashitani has been Professor of Cell Physiology at Nagoya City University since 2010.  He received his medical degree from Kyushu University, completed his PhD at Nagoya City University, and then studied at Melbourne University and University of Oxford.  His research interests have primarily focused on cellular mechanisms underlying spontaneous electrical and calcium signalling in smooth muscle of the genitourinary, gastrointestinal and microvascular systems.
Richard Lang received his PhD at Monash University in 1979. He was an MRC Research Officer and Fellow at St George’s Hospital Medical School, London. He returned to Monash University as a Research Fellow and has continued as a Senior Research Fellow. Throughout, he has been interested in the role membrane ion channels and calcium play in pacemaker and tone generation in both gastrointestinal and urogenital organs.
Hikaru Hashitani and Richard Lang have collaborated for over 20 years, exchanging a number of graduate students for short term visits and one PhD graduate on a  JSPS Fellowship. Over this time, we have together published 20 papers and numerous conference abstracts on the electrical and calcium signalling properties of the renal pelvis, urethra and prostate.  This collaboration is a continuation of a long-held tradition of international collaboration between British, Japanese and Australian smooth muscle researchers that originated by our mentors in Oxford University in the 1960s.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles

    Pages 3-46

    Sanders, Kenton M.

  • Generation of Spontaneous Tone by Gastrointestinal Sphincters

    Pages 47-74

    Keef, Kathleen (et al.)

  • Pacemaker Mechanisms Driving Pyeloureteric Peristalsis: Modulatory Role of Interstitial Cells

    Pages 77-101

    Lang, Richard J. (et al.)

  • Excitation-Contraction Coupling in Ureteric Smooth Muscle: Mechanisms Driving Ureteric Peristalsis

    Pages 103-119

    Burdyga, Theodor (et al.)

  • Spontaneous Activity and the Urinary Bladder

    Pages 121-147

    Fry, Christopher H. (et al.)

Buy this book

eBook 130,89 €
price for Spain (gross)
  • ISBN 978-981-13-5895-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-981-13-5894-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Smooth Muscle Spontaneous Activity
Book Subtitle
Physiological and Pathological Modulation
Editors
  • Hikaru Hashitani
  • Richard J. Lang
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1124
Copyright
2019
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-13-5895-1
DOI
10.1007/978-981-13-5895-1
Hardcover ISBN
978-981-13-5894-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIX, 427
Number of Illustrations
46 b/w illustrations, 63 illustrations in colour
Topics