Antimicrobial Peptides

1. Front Matter

   Pages i-viii

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Antimicrobial Peptides of Multicellular Organisms: My Perspective

      • Michael Zasloff

      Pages 3-6

3. Mechanisms of Antimicrobial Action

   1. Front Matter

      Pages 7-7

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   2. Membrane Permeabilization Mechanisms

      • Katsumi Matsuzaki

      Pages 9-16

   3. Elementary Processes and Mechanisms of Interactions of Antimicrobial Peptides with Membranes—Single Giant Unilamellar Vesicle Studies—

      • Moynul Hasan, Masahito Yamazaki

      Pages 17-32

   4. The Mechanisms of Action of Cationic Antimicrobial Peptides Refined by Novel Concepts from Biophysical Investigations

      • Christopher Aisenbrey, Arnaud Marquette, Burkhard Bechinger

      Pages 33-64

   5. Anionic Lipid Clustering Model

      • Richard M. Epand

      Pages 65-71

   6. Intracellular Antimicrobial Peptides Targeting the Protein Synthesis Machinery

      • Michael Graf, Daniel N. Wilson

      Pages 73-89

4. Other Activities of AMPs

   1. Front Matter

      Pages 91-91

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   2. Antimicrobial and Cell-Penetrating Peptides: How to Understand Two Distinct Functions Despite Similar Physicochemical Properties

      • Ines Neundorf

      Pages 93-109

   3. Synthetic Anti-lipopolysaccharide Peptides (SALPs) as Effective Inhibitors of Pathogen-Associated Molecular Patterns (PAMPs)

      • Wilmar Correa, Lena Heinbockel, Guillermo Martinez-de-Tejada, Susana Sánchez, Patrick Garidel, Tobias Schürholz et al.

      Pages 111-129

   4. Anticancer Activities of Natural and Synthetic Peptides

      • A. L. Hilchie, D. W. Hoskin, M. R. Power Coombs

      Pages 131-147

   5. Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects

      • Anne M. van der Does, Pieter S. Hiemstra, Neeloffer Mookherjee

      Pages 149-171

5. Towards Clinical Applications

   1. Front Matter

      Pages 173-173

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   2. Selectivity of Antimicrobial Peptides: A Complex Interplay of Multiple Equilibria

      • Sara Bobone, Lorenzo Stella

      Pages 175-214

   3. Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37

      • Guangshun Wang, Jayaram Lakshmaiah Narayana, Biswajit Mishra, Yingxia Zhang, Fangyu Wang, Chunfeng Wang et al.

      Pages 215-240

   4. Application of Synthetic Molecular Evolution to the Discovery of Antimicrobial Peptides

      • William C. Wimley

      Pages 241-255

   5. AMPs as Anti-biofilm Agents for Human Therapy and Prophylaxis

      • Hawraa Shahrour, Raquel Ferrer-Espada, Israa Dandache, Sergio Bárcena-Varela, Susana Sánchez-Gómez, Ali Chokr et al.

      Pages 257-279

   6. Clinical Application of AMPs

      • Fabíola Costa, Cátia Teixeira, Paula Gomes, M. Cristina L. Martins

      Pages 281-298

This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

• Mechanism of action
• Antisepsis agent
• Anticancer agent
• Clinical application
• Peptide translocation

• Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Japan

  Katsumi Matsuzaki

Katsumi Matsuzaki is a Professor at the Graduate School of Pharmaceutical Sciences, Kyoto University, where he also completed his PhD in Biophysical Chemistry. Dr. Matsuzaki has authored more than 100 publications, which have been cited more than 10000 times. In addition to serving as an editor for Biochimica et Biophysica Acta-Biomembranes, Journal of Peptide Science, and European Biophysics Journal, he is a member of the Biophysical Society (USA), The Pharmaceutical Society Japan, The Japanese Peptide Society, and The Biophysical Society of Japan. He was awarded The Japanese Peptide Society Award for Young Scientists, The Pharmaceutical Society Japan Award for Young Scientists, and the Erwin von Bälz Prize. His primary research interest is in membrane biophysics, including peptide–membrane interactions and in-cell biophysics.

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