Learning Materials in Biosciences

Introduction to Synthetic Biology

About Modeling, Computation, and Circuit Design

Authors: Marchisio, Mario Andrea

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  • Explains how to make mathematical models of synthetic gene circuits
  • Presents concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization
  • Shows how to build up models for synthetic gene circuits with four different open-source software
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eBook 67,40 €
price for Spain (gross)
  • ISBN 978-981-10-8752-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
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  • Immediate eBook download after purchase
Softcover 83,19 €
price for Spain (gross)
  • ISBN 978-981-10-8751-6
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  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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About this Textbook

The textbook is based on the lectures of the course “Synthetic Biology” for Master’s students in biology and biotechnology at the Harbin Institute of Technology. The goal of the textbook is to explain how to make mathematical models of synthetic gene circuits that will, later on, drive the circuit implementation in the lab. Concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization are presented. At the end of the textbook, a chapter contains a description of structural motifs (e.g. positive and negative feedback loops, Boolean gates) that carry out specific functions and can be combined into larger networks. Moreover, several chapters show how to build up (an analyse, where possible) models for synthetic gene circuits with four different open-source software i.e. COPASI, XPPAUT, BioNetGeN, and Parts & Pools-ProMoT.

About the authors

Mario Andrea Marchisio has obtained his PhD in Physics at the University of Trento, Italy in 2002. After working for four years at the CILEA computing center in Milan, Italy, he spent six years as a Post Doc at the ETH Zurich, Switzerland. Since September 2013, he is working as an Associate Professor in Synthetic Biology at the Harbin Institute of Technology, China.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Introduction

    Pages 1-5

    Marchisio, Mario Andrea

  • Modeling: Choosing a Kinetics

    Pages 7-28

    Marchisio, Mario Andrea

  • Modeling at Computer: Getting Started

    Pages 29-38

    Marchisio, Mario Andrea

  • Stochastic Modeling

    Pages 39-52

    Marchisio, Mario Andrea

  • Stability Analysis: Steady States

    Pages 53-65

    Marchisio, Mario Andrea

Buy this book

eBook 67,40 €
price for Spain (gross)
  • ISBN 978-981-10-8752-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 83,19 €
price for Spain (gross)
  • ISBN 978-981-10-8751-6
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Introduction to Synthetic Biology
Book Subtitle
About Modeling, Computation, and Circuit Design
Authors
Series Title
Learning Materials in Biosciences
Copyright
2018
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-8752-3
DOI
10.1007/978-981-10-8752-3
Softcover ISBN
978-981-10-8751-6
Series ISSN
2509-6125
Edition Number
1
Number of Pages
XII, 187
Number of Illustrations
17 b/w illustrations, 74 illustrations in colour
Topics