The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery
Editors: Suzuki, Makoto (Ed.)
Free Preview- Provides approaches to the essence of life functions
- Links biology and chemical physics
- Sets forth revolutionary concepts for biological molecular functions
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- About this book
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This book introduces recent progress in biological energetics from ATP hydrolysis to molecular machineries. The role of water is now recognized to be essential in biological molecular energetics. Although energetics is a rather distant field to many biologists, any working models for protein machineries such as protein motors, transporters, and other enzymes must be consistent with their energetics. Therefore, the book is intended to help scientists build systematic models of biomolecular functions based on three categories: (1) ATP hydrolysis reactions including ionic hydration and protonation–deprotonation of biomolecules, (2) protein–ligand/protein–protein interactions including hydration–dehydration processes, and (3) functioning mechanisms of protein machineries based on water functions.
- About the authors
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Makoto Suzuki graduated from Yamagata University in 1974 and received his Doctor of Engineering degree from Tohoku University in 1981. Following his studies, he worked at the Mechanical Engineering Laboratory (MEL/AIST) for eleven years, and at the National Institute for Advanced Interdisciplinary Research (NAIR/AIST) for five years. He moved from NAIR to Tohoku University as a professor in 1996. Using his improved-high-precision system of dielectric spectroscopy, he discovered hyper-mobile water (HMW) in the hydration layer of actin filaments, one of the contractile muscle proteins, in 2003. He organized "Water Plays the Main Role in ATP Energy Transfer" (2008-2012) as an Innovative Scientific Research Area, an interdisciplinary project focused on the energetics of protein machineries.
- Table of contents (20 chapters)
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Free Energy Analyses for the ATP Hydrolysis in Aqueous Solution by Large-Scale QM/MM Simulations Combined with a Theory of Solutions
Pages 3-23
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Role of Metal Ion Binding and Protonation in ATP Hydrolysis Energetics
Pages 25-32
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Spatial Distribution of Ionic Hydration Energy and Hyper-Mobile Water
Pages 33-52
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Theoretical Studies of Strong Attractive Interaction Between Macro-anions Mediated by Multivalent Metal Cations and Related Association Behavior: Effective Interaction Between ATP-Binding Proteins Can Be Regulated by Hydrolysis
Pages 53-67
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Statistical Mechanical Integral Equation Approach to Reveal the Solvation Effect on Hydrolysis Free Energy of ATP and Its Analogue
Pages 69-85
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Table of contents (20 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- The Role of Water in ATP Hydrolysis Energy Transduction by Protein Machinery
- Editors
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- Makoto Suzuki
- Copyright
- 2018
- Publisher
- Springer Singapore
- Copyright Holder
- Springer Nature Singapore Pte Ltd.
- eBook ISBN
- 978-981-10-8459-1
- DOI
- 10.1007/978-981-10-8459-1
- Hardcover ISBN
- 978-981-10-8458-4
- Softcover ISBN
- 978-981-13-4157-1
- Edition Number
- 1
- Number of Pages
- IX, 353
- Number of Illustrations
- 24 b/w illustrations, 100 illustrations in colour
- Topics
