MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
Editors: Anderluh, Gregor, Gilbert, Robert (Eds.)
Free Preview- A comprehensive overview of one of the largest pore forming proteins superfamilies
- A special chapter on methodology allowing the study of mechanisms of pore formation
- Several novel data reviews which provide new insights into the distribution of MACPF/CDC proteins throughout biology
- In depth perspectives on MACPF/CDCs from multiple fields of study: medicine, biology, biophysics, applications-based, technical development
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- About this book
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This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.
The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.
- Table of contents (15 chapters)
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Introduction: Brief Historical Overview
Pages 3-6
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Distribution of MACPF/CDC Proteins
Pages 7-30
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Evolution of the Complement System
Pages 31-43
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Structural Features of Cholesterol Dependent Cytolysins and Comparison to Other MACPF-Domain Containing Proteins
Pages 47-62
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Perfringolysin O Structure and Mechanism of Pore Formation as a Paradigm for Cholesterol-Dependent Cytolysins
Pages 63-81
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Table of contents (15 chapters)
- Download Preface 1 PDF (57.3 KB)
- Download Sample pages 2 PDF (950.9 KB)
- Download Table of contents PDF (85.9 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
- Editors
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- Gregor Anderluh
- Robert Gilbert
- Series Title
- Subcellular Biochemistry
- Series Volume
- 80
- Copyright
- 2014
- Publisher
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media Dordrecht
- eBook ISBN
- 978-94-017-8881-6
- DOI
- 10.1007/978-94-017-8881-6
- Hardcover ISBN
- 978-94-017-8880-9
- Softcover ISBN
- 978-94-024-0339-8
- Series ISSN
- 0306-0225
- Edition Number
- 1
- Number of Pages
- XI, 329
- Number of Illustrations
- 5 b/w illustrations, 52 illustrations in colour
- Topics
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