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Developments in Oncology

Application of Monoclonal Antibodies in Tumor Pathology

Editors: Ruiter, Dirk J., Fleuren, G.J., Warnaar, S.O. (Eds.)

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  • ISBN 978-94-009-3299-9
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About this book

The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues. During the last few years this approach has been utilized by a progressively increasing number of investigators to analyze malignant cells. Although monoclonal antibodies to tumor associated antigens have not become yet routine reagents in immunopathology, they have provided new information which could not be obtained with conventional antisera or histochemical procedures. The following are representative examples. TUmor associated antigens have been identified which display a restricted distribution in normal tissues and therefore may represent useful markers for radio­ imaging and appropriate targets for immunotherapy. In spite of undetec­ table differences with conventional histopathological approaches hetero­ geneity has been found in the antigenic profile of tumor cells within a lesion, in autologous lesions removed from different anatomic sites from a given patient and in lesions removed from different patients. Phenotypes of tumor cells have been identified which correlate with the biology of tumor cells and with the clinical course of the disease. From a practical view point the use of monoclonal antibodies in immunopathology has enhanced interactions between pathologists and immunologists, as exemplified by the present book. Such interactions have contributed to the application of basic research to clinical problems. The chapter of this book discuss investigations performed with monoclonal antibodies to antigens expressed by various types of normal and malignant human cells.

Table of contents (26 chapters)

Table of contents (26 chapters)

Buy this book

eBook 91,62 €
price for Spain (gross)
  • ISBN 978-94-009-3299-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 114,39 €
price for Spain (gross)
  • ISBN 978-94-010-7981-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Application of Monoclonal Antibodies in Tumor Pathology
Editors
  • Dirk J. Ruiter
  • G.J. Fleuren
  • S.O. Warnaar
Series Title
Developments in Oncology
Series Volume
50
Copyright
1987
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-009-3299-9
DOI
10.1007/978-94-009-3299-9
Softcover ISBN
978-94-010-7981-5
Edition Number
1
Number of Pages
XII, 391
Number of Illustrations
82 b/w illustrations
Topics