Aging Research in Yeast
Editors: Breitenbach, Michael, Jazwinski, S. Michal, Laun, Peter (Eds.)
Free Preview- Yeast aging research and its relevance to humans
- Thorough account of a rapidly expanding field
- Offers a molecular cell biology perspective on aging
- Written by authorities in the field of aging research
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- About this book
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This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.
- Reviews
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From the reviews:
“This book compiles some of the most exciting and promising research to date in the fields of anti-aging, longevity, and possibly even rejuvenation. The authors’ research examines the role of senescence in yeast and how it may relate to the chaotic autophagy of cancer cells. In sum, Aging Research will stir interest in both scientific and non-scientific arenas.” (The Electric Review, October, 2012)
- Table of contents (15 chapters)
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Introduction
Pages 1-12
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Oxidative Stresses and Ageing
Pages 13-54
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The Role of Mitochondria in the Aging Processes of Yeast
Pages 55-78
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The Retrograde Response and Other Pathways of Interorganelle Communication in Yeast Replicative Aging
Pages 79-100
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Chronological Aging in Saccharomyces cerevisiae
Pages 101-121
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Table of contents (15 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Aging Research in Yeast
- Editors
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- Michael Breitenbach
- S. Michal Jazwinski
- Peter Laun
- Series Title
- Subcellular Biochemistry
- Series Volume
- 57
- Copyright
- 2012
- Publisher
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media B.V.
- eBook ISBN
- 978-94-007-2561-4
- DOI
- 10.1007/978-94-007-2561-4
- Hardcover ISBN
- 978-94-007-2560-7
- Softcover ISBN
- 978-94-007-9420-7
- Series ISSN
- 0306-0225
- Edition Number
- 1
- Number of Pages
- XII, 368
- Topics
