- Provides the recent advances in molecular mechanisms of wound healing
- Provides in-depth information on roles of lactoferrin as a signaling molecule
- Presents the scientific background on use of lactoferrin as a wound healing agent
Buy this book
- About this book
-
Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers.
- Table of contents (5 chapters)
-
-
Molecular Regulation of Skin Wound Healing
Pages 1-23
-
Role of Hyaluronan in Wound Healing
Pages 25-42
-
Lactoferrin Structure Function and Genetics
Pages 43-66
-
Lactoferrin as a Signaling Mediator
Pages 67-85
-
Effects of Lactoferrin on Skin Wound Healing
Pages 87-100
-
Table of contents (5 chapters)
Recommended for you
Bibliographic Information
- Bibliographic Information
-
- Book Title
- Lactoferrin and its Role in Wound Healing
- Authors
-
- Yoshiharu Takayama
- Copyright
- 2012
- Publisher
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media B.V.
- eBook ISBN
- 978-94-007-2467-9
- DOI
- 10.1007/978-94-007-2467-9
- Hardcover ISBN
- 978-94-007-2466-2
- Softcover ISBN
- 978-94-007-9202-9
- Edition Number
- 1
- Number of Pages
- XII, 108
- Topics
