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  • © 2011

Cancer Systems Biology, Bioinformatics and Medicine

Research and Clinical Applications

  • The world’s top experts describe systems approaches to cancer research and application
  • Is uniquely organized to unify all aspects from laboratory to clinic
  • Demonstrates how systems approaches build upon and greatly extend and unify current research practices
  • Demonstrates that cancer systems approaches form a unified field that has already produced major applications
  • A full range of subjects is covered, spanning laboratory, clinical and medical approaches
  • Includes supplementary material: sn.pub/extras

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Table of contents (19 chapters)

  1. Front Matter

    Pages 1-1
  2. Introduction and Background

    1. Front Matter

      Pages 1-1
    2. Introduction to Systems Approaches to Cancer

      • Frederick B. Marcus, Alfredo Cesario
      Pages 3-27
    3. Cancer: Clinical Background and Key Challenges

      • Antonio Llombart-Bosch, Ulrik Ringborg, Sergio Rutella, Julio E. Celis
      Pages 29-93
  3. Laboratory, Clinical, Data and Educational Resources

    1. Front Matter

      Pages 95-95
    2. Global Molecular and Cellular Measurement Technologies

      • Bodo M. H. Lange, Michal R. Schweiger, Hans Lehrach
      Pages 97-126
    3. Education and Research Infrastructures

      • Anna Tramontano, Alfonso Valencia
      Pages 165-181
  4. Bioinformatics and Systems Biology Analysis

    1. Front Matter

      Pages 183-183
    2. Mathematical Tools in Cancer Signalling Systems Biology

      • Julio Vera, Olaf Wolkenhauer
      Pages 185-212
    3. Computational Tools for Systems Biology

      • Edda Klipp, Falko Krause
      Pages 213-243
    4. The Hallmarks of Cancer Revisited Through Systems Biology and Network Modelling

      • Charles Auffray, Trey Ideker, David J. Galas, Leroy Hood
      Pages 245-266
    5. Systems Biology, Bioinformatics and Medicine Approaches to Cancer Progression Outcomes

      • Jan G. Hengstler, Mathias Gehrmann, Stefan Höhme, Dirk Drasdo, Joanna D. Stewart, Marcus Schmidt
      Pages 297-307
  5. Diagnosis, Clinical and Treatment Applications

    1. Front Matter

      Pages 327-327
    2. Systems Biology Approaches to Cancer Drug Development

      • Christopher Snell, David Orrell, Eric Fernandez, Christophe Chassagnole, David Fell
      Pages 367-380
    3. Circadian Rhythms and Cancer Chronotherapeutics

      • Francis LĂ©vi, Atilla Altinok, Albert Goldbeter
      Pages 381-407

About this book

This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods.  Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these tools and methods to clinical diagnosis, drug development and treatment applications; and 5) Finishes by exploring longer term perspectives and providing conclusions. This book reviews the state-of-the-art, and goes beyond into new applications. It is written and highly referenced as a textbook and practical guide aimed at students, academics, doctors, clinicians, industrialists and managers in cancer research and therapeutic applications. Ideally, it will set the stage for integration of available knowledge to optimize communication between basic and clinical researchers involved in the ultimate fight against cancer, whatever the field of specific interest, whatever the area of activity within translational research.

Editors and Affiliations

  • Rome, Italy

    Alfredo Cesario

  • Rixensart, Belgium

    Frederick Marcus

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access