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Subcellular Biochemistry

Genome Stability and Human Diseases

Editors: Nasheuer, Heinz-Peter (Ed.)

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  • Discusses cancer cell biology in relation to Genome stability and Cell cycle regulation
  • Unique assembly of experts in these fields who wrote a comprehensive and deep up-to-date overview
  • Discusses models for the understanding of DNA damage-dependent signal transduction and regulation in human cells
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eBook 171,19 €
price for Spain (gross)
  • ISBN 978-90-481-3471-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 228,79 €
price for Spain (gross)
Softcover 213,81 €
price for Spain (gross)
About this book

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.

This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Table of contents (17 chapters)

Table of contents (17 chapters)

Buy this book

eBook 171,19 €
price for Spain (gross)
  • ISBN 978-90-481-3471-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 228,79 €
price for Spain (gross)
Softcover 213,81 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Genome Stability and Human Diseases
Editors
  • Heinz-Peter Nasheuer
Series Title
Subcellular Biochemistry
Series Volume
50
Copyright
2010
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-90-481-3471-7
DOI
10.1007/978-90-481-3471-7
Hardcover ISBN
978-90-481-3470-0
Softcover ISBN
978-94-007-3125-7
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XVI, 340
Topics