Comparative Biology of Aging

1. Front Matter

   Pages i-ix

   PDF

2. Introduction: Lifespans and Pathologies Present at Death in Laboratory Animals

   • Norman S. Wolf, Steven Austad

   Pages 1-26

3. Animal Size, Metabolic Rate, and Survival, Among and Within Species

   • Steven N. Austad

   Pages 27-41

4. Hormonal Influences on Aging and Lifespan

   • Adam Spong, Andrzej Bartke

   Pages 43-68

5. Exploring Mechanisms of Aging Retardation by Caloric Restriction: Studies in Model Organisms and Mammals

   • Rozalyn M. Anderson, Ricki J. Colman, Richard Weindruch

   Pages 69-96

6. Cell Replication Rates In Vivo and In Vitro and Wound Healing as Affected by Animal Age, Diet, and Species

   • Norman S. Wolf

   Pages 97-122

7. Sirtuin Function in Longevity

   • Daniel L. Smith Jr., Jeffrey S. Smith

   Pages 123-146

8. The Role of TOR Signaling in Aging

   • Matt Kaeberlein, Lara S. Shamieh

   Pages 147-161

9. Mitochondria, Oxidative Damage and Longevity: What Can Comparative Biology Teach Us?

   • Yun Shi, Rochelle Buffenstein, Holly Van Remmen

   Pages 163-190

10. Comparative Genomics of Aging

    • Jan Vijg, Ana Maria Garcia, Brent Calder, Martijn Dollé

    Pages 191-200

11. Changes in Lysosomes and Their Autophagic Function in Aging: The Comparative Biology of Lysosomal Function

    • Samantha J. Orenstein, Ana Maria Cuervo

    Pages 201-226

12. Telomeres and Telomerase

    • N.M.V. Gomes, J.W. Shay, W. E. Wright

    Pages 227-258

13. Cardiac Aging

    • Dao-Fu Dai, Robert J. Wessells, Rolf Bodmer, Peter S. Rabinovitch

    Pages 259-286

14. Comparative Skeletal Muscle Aging

    • David J. Marcinek, Jonathan Wanagat, Jason J. Villarin

    Pages 287-317

15. Aging of the Nervous System

    • Catherine A. Wolkow, Sige Zou, Mark P. Mattson

    Pages 319-352

16. Aging of the Immune System Across Different Species

    • Janko Nikolich-Žugich, Luka Čičin-Šain

    Pages 353-376

17. Back Matter

    Pages 377-391

    PDF

determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].

• DNA
• Gerontology
• Immune System
• Organelle
• Telomere
• Vivo
• influence

• Seattle, U.S.A.

  Norman S. Wolf

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