New Challenges for Cancer Systems Biomedicine
Editors: D'Onofrio, Alberto, Cerrai, Paola, Gandolfi, Alberto (Eds.)
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- About this book
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The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.
- About the authors
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Alberto d’Onofrio is principal investigator in Systems Biomedicine at the European Institute of Oncology. His research interests focus on the application of mathematical and theoretical physics methodologies to study tumor biology, and the spread of infectious diseases. Webpage: http://www.ifom-ieo-campus.it/research/donofrio.php
Paola Cerrai is researcher at the Department of Mathematics of Pisa University, where she lectures in Mathematics and Statistics at the faculty of Biology. Her research interests focus on Mathematical Biology and Medicine. In particular: population dynamics, motion of bacteria and, more recently, growth of tumours and their interactions with the Immune System. She is also interested in the process (and in the related difficulties) of learning probability and statistics. She is intensely active in promoting the interdisciplinary cultural dialogue by organizing conferences and seminars.
Alberto Gandolfi works at Istituto di analisi dei Sistemi e di Informatica.
- Table of contents (20 chapters)
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Combining Game Theory and Graph Theory to Model Interactions between Cells in the Tumor Microenvironment
Pages 3-18
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Growth as the Root of all Evil in Carcinomas: Synergy between pH Buffering and Anti-Angiogenesis Prevents Emergence of Hallmarks of Cancer
Pages 19-34
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Phase Transitions in Cancer
Pages 35-51
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Spatio-Temporal Modelling of Intracellular Signalling Pathways: Transcription Factors, Negative Feedback Systems and Oscillations
Pages 55-82
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Understanding Cell Fate Decisions by Identifying Crucial System Dynamics
Pages 83-104
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Table of contents (20 chapters)
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- Download Table of contents PDF (61.3 KB)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- New Challenges for Cancer Systems Biomedicine
- Editors
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- Alberto D'Onofrio
- Paola Cerrai
- Alberto Gandolfi
- Series Title
- SEMA SIMAI Springer Series
- Copyright
- 2012
- Publisher
- Springer-Verlag Mailand
- Copyright Holder
- Springer-Verlag Italia Srl.
- eBook ISBN
- 978-88-470-2571-4
- DOI
- 10.1007/978-88-470-2571-4
- Hardcover ISBN
- 978-88-470-2570-7
- Softcover ISBN
- 978-88-470-5617-6
- Series ISSN
- 2199-3041
- Edition Number
- 1
- Number of Pages
- XII, 400
- Topics
