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Recent Results in Cancer Research

Peptides in Oncology I

LH-RH Agonists and Antagonists

Editors: Höffken, K. (Ed.)

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About this book

Hormonal treatment of malignant diseases has been used for quite some years now, and progress in this field is still being made at a steady pace. The detection of new endocrine feed­ back loops and the availability of new classes of hormonal agents made hormonal intervention with predictable outcome possible. Besides the intellectual challenge of modulating the hormone system, an important aspect of recent research on hormones and cancer is the reduction of treatment-related morbidity achieved with the new hormonal strategies. Thus, controlled intervention in the hypothalamic-gonadotropic axis is increasingly apt to replace surgical removal of the relevant glands, i. e. , the pituitary gland or the gonads. In the same way as, for example, aromatase inhibitors are being used as a substitute for adrenalectomy. The concept that secretion of hypothalamic gonadotropin­ releasing hormone (GnRH), pituitary gonadotropins, and sex steroids are regulated via negative and positive feedback loops is based on the pioneering work of Hohlweg and Harris some 40 years ago. In 1971, a breakthrough was achieved with the isolation, structural analysis, and synthesis of the luteinizing hormone releasing hormone (LH-RH), or GnRH as it is now more appropriately termed, since it provokes the secretion of both gonadotropins, LH and FSH, and since then the progress made in this area of research has been remarkable. Both ago­ nists and antagonists of LH-RH have been synthesized and extensively studied in preclinical and clinical settings.

Table of contents (11 chapters)

Table of contents (11 chapters)

Buy this book

eBook 58,84 €
price for Spain (gross)
  • ISBN 978-88-470-2186-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 72,79 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Peptides in Oncology I
Book Subtitle
LH-RH Agonists and Antagonists
Editors
  • K. Höffken
Series Title
Recent Results in Cancer Research
Series Volume
124
Copyright
1992
Publisher
Springer-Verlag Mailand
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-88-470-2186-0
DOI
10.1007/978-88-470-2186-0
Softcover ISBN
978-88-470-2188-4
Series ISSN
0080-0015
Edition Number
1
Number of Pages
XII, 141
Number of Illustrations
6 b/w illustrations
Topics