Muse Cells

1. Front Matter

   Pages i-xii

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2. The Muse Cell Discovery, Thanks to Wine and Science

   • Mari Dezawa

   Pages 1-11

3. Basic Characteristics of Muse Cells

   • Shohei Wakao, Yoshihiro Kushida, Mari Dezawa

   Pages 13-41

4. Muse Cells Are Endogenous Reparative Stem Cells

   • Yoshihiro Kushida, Shohei Wakao, Mari Dezawa

   Pages 43-68

5. Protocols for Isolation and Evaluation of Muse Cells

   • Kazuki Tatsumi, Yoshihiro Kushida, Shohei Wakao, Yasumasa Kuroda, Mari Dezawa

   Pages 69-101

6. Stem Cells and DNA Repair Capacity: Muse Stem Cells Are Among the Best Performers

   • Tiziana Squillaro, Nicola Alessio, Giovanni Di Bernardo, Servet Özcan, Gianfranco Peluso, Umberto Galderisi

   Pages 103-113

7. Immunomodulatory Properties and Potential Therapeutic Benefits of Muse Cells Administration in Diabetes

   • Marcelo Javier Perone, María Laura Gimeno, Florencia Fuertes

   Pages 115-129

8. The Role of the Mitochondria in the Evolution of Stem Cells, Including MUSE Stem Cells and Their Biology

   • James E. Trosko

   Pages 131-152

9. Acute Myocardial Infarction, Cardioprotection, and Muse Cells

   • Shinya Minatoguchi, Atsushi Mikami, Toshiki Tanaka, Shingo Minatoguchi, Yoshihisa Yamada

   Pages 153-166

10. Application of Muse Cell Therapy to Stroke

    • Kuniyasu Niizuma, Cesar V. Borlongan, Teiji Tominaga

    Pages 167-186

11. Muse Cell: A New Paradigm for Cell Therapy and Regenerative Homeostasis in Ischemic Stroke

    • Satoshi Kuroda, Masaki Koh, Emiko Hori, Yumiko Hayakawa, Takuya Akai

    Pages 187-198

12. Application of Muse Cell Therapy for Kidney Diseases

    • Nao Uchida, Naonori Kumagai, Yoshiaki Kondo

    Pages 199-218

13. Liver Regeneration Supported by Muse Cells

    • Satoshi S. Nishizuka, Yuji Suzuki, Hirokatsu Katagiri, Yasuhiro Takikawa

    Pages 219-241

14. Current Cell-Based Therapies in the Chronic Liver Diseases

    • Taketo Nishina, Kyoko Tomita Hoshikawa, Yoshiyuki Ueno

    Pages 243-253

15. Artificial Pigmented Human Skin Created by Muse Cells

    • Takeshi Yamauchi, Kenshi Yamasaki, Kenichiro Tsuchiyama, Setsuya Aiba

    Pages 255-271

16. Muse Cells and Aortic Aneurysm

    • Katsuhiro Hosoyama, Yoshikatsu Saiki

    Pages 273-291

17. Muse Cells and Ischemia-Reperfusion Lung Injury

    • Hiroshi Yabuki, Tatsuaki Watanabe, Hisashi Oishi, Masato Katahira, Masahiko Kanehira, Yoshinori Okada

    Pages 293-303

18. Clinical Trials of Muse Cells

    • Mari Dezawa

    Pages 305-307

19. Future of Muse Cells

    • Wise Young

    Pages 309-315

20. Correction to: Basic Characteristics of Muse Cells

    • Shohei Wakao, Yoshihiro Kushida, Mari Dezawa

    Pages C1-C1

This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhancethe effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.

• Mesenchymal stem cells
• Non-tumorigenicity
• Pluripotent stem cells
• Regenerative medicine
• Tissue engineering
• Tissue homeostasis

• Tohoku University Graduate School of Medicine, Sendai, Japan

  Mari Dezawa

Mari Dezawa, M.D., Ph.D., is professor and chairperson at the Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine (Japan). She has contributed to regenerative medicine by discovering non-tumorigenic reparative pluripotent stem cells, multilineage-differentiating stress-enduring (Muse) cells that naturally reside in the living body. Dr. Dezawa graduated from Chiba University School of Medicine in 1989 and gained her Ph.D. from the same university in 1995. In 2000 she joined Yokohama City University, where she started mesenchymal stem cell (MSC) research. After moving to Kyoto University Graduate School of Medicine as associate professor in 2003, she discovered methods to induce neurons and skeletal muscle cells from human MSCs by combining gene introduction and cytokine stimulation. In 2008, she became professor and chair of the Department of Stem Cell Biology and Histology at Tohoku University Graduate School of Medicine. She subsequently has published a number of articles in leading journals on Muse cells and their reparative functions in animal disease models. Dr. Dezawa is the author of more than 120 original articles in international journals and serves as an editorial board member of several international journals. She is a fellow of the National Academy of Inventors, USA.

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