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Metallomics

Recent Analytical Techniques and Applications

Editors: Ogra, Yasumitsu, Hirata, Takafumi (Eds.)

  • Provides basic and advanced analytical techniques and molecular biology for metallomics
  • Examines medical and pharmaceutical implications
  • Presents unique features of hybriding of elemental imaging and matrix assisted laser desorption / ionization (MALDI) imaging
  • Highlights recent progress in the ICP-MS and the related technique
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Buy this book

eBook 142,79 €
price for Spain (gross)
  • ISBN 978-4-431-56463-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 176,79 €
price for Spain (gross)
  • ISBN 978-4-431-56461-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 176,79 €
price for Spain (gross)
  • ISBN 978-4-431-56793-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.

About the authors

Yasumitsu Ogra
Professor, Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, 1‐8‐1 Inohana, Chuo‐ku, Chiba 260‐8675, Japan

Takafumi Hirata
Professor, Earth and Planetary Sciences, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake‐cho, Sakyo‐ku, Kyoto 606‐8502, Japan

Reviews

“Metallomics: recent analytical techniques and applications seems adequate for Ph.D. students who are trying to approach the topic of metallomics as well as for scientists working in this discipline to update their knowledge of the field. … It provides an overview of fundamental principles, problems and tools for the analysis of biomolecules.” (Maria Montes-Bayón, Analytical and Bioanalytical Chemistry, Vol. 410, 2018)​

Table of contents (16 chapters)

  • Metallomics: Integrated Biometal Science

    Haraguchi, Hiroki

    Pages 3-39

    Preview Buy Chapter 30,19 €
  • Speciation and Identification of Chalcogen-Containing Metabolites

    Ogra, Yasumitsu, Ph.D.

    Pages 43-61

    Preview Buy Chapter 30,19 €
  • Visualization of Intracellular Elements Using Scanning X-Ray Fluorescence Microscopy

    Shimura, Mari (et al.)

    Pages 63-92

    Preview Buy Chapter 30,19 €
  • Quantitative Elemental Bioimaging Protocol Using Femtosecond-Laser Ablation-ICP-Mass Spectrometry Coupled with Glass Standard Reference Material

    Makino, Yoshiki (et al.)

    Pages 93-106

    Preview Buy Chapter 30,19 €
  • Single Cell Analysis by Using ICP-MS

    Miyashita, Shin-ichi (et al.)

    Pages 107-124

    Preview Buy Chapter 30,19 €

Buy this book

eBook 142,79 €
price for Spain (gross)
  • ISBN 978-4-431-56463-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 176,79 €
price for Spain (gross)
  • ISBN 978-4-431-56461-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 176,79 €
price for Spain (gross)
  • ISBN 978-4-431-56793-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Metallomics
Book Subtitle
Recent Analytical Techniques and Applications
Editors
  • Yasumitsu Ogra
  • Takafumi Hirata
Copyright
2017
Publisher
Springer Japan
Copyright Holder
Springer Japan KK
eBook ISBN
978-4-431-56463-8
DOI
10.1007/978-4-431-56463-8
Hardcover ISBN
978-4-431-56461-4
Softcover ISBN
978-4-431-56793-6
Edition Number
1
Number of Pages
VIII, 364
Number of Illustrations and Tables
61 b/w illustrations, 76 illustrations in colour
Topics