Editors:
- Provides a comprehensive summary of recent studies on lipid mediators and related molecules
- Offers step-by-step procedures for analysis of lipid mediators and their receptors
- Suggests new drug targets for inflammatory diseases
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Table of contents (29 chapters)
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Front Matter
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Enzymes and Receptors for Lipid Mediators
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Front Matter
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Lipid Mediators in Drosophila and Zebrafish
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Front Matter
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Lipid Mediators and Diseases
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Front Matter
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About this book
This book summarizes the most recent progress in the studies of lipid mediators from the molecular to clinical level and introduces newly created tools for analysis including imaging mass spectrometry. Comprising 29 chapters divided into four major parts, the book describes the molecular natures of enzymes, transporters, and receptors for lipid mediators (Part I), the function of lipid mediators in Drosophila and Zebrafish (Part II), the relationships between lipid mediators and various diseases (Part III), and detailed procedures of extraction, preparation, and quantification of lipid mediators (Part IV). Research on lipid mediators initially started with analysis of the action of aspirin, and subsequent biochemical experiments identified many enzymes and receptors responsible for the biosynthesis and signal transduction of individual lipid mediators. Through the phenotypic analyses of transgenic and knockout mice, it has been shown that the dysregulation of some lipid mediators causes inflammatory, immune, or oncogenic disorders. Lipid mediators have attracted increased attention because their structures are conserved among different species, and their biosynthetic and signaling pathways have been deciphered at the molecular level. Many drugs that target lipid mediators are already being used in hospitals, and this book suggests further possibilities for development of a wide variety of such drugs. Very recently, highly sensitive mass spectrometry has begun to be used to identify novel lipid mediators that are present only in trace amounts in tissues but with robust biological activity. Written by international experts, this book provides readers a comprehensive view of lipid mediators and related topics and helps in the process of determining research targets for the near future.
Editors and Affiliations
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Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan
Takehiko Yokomizo
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Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
Makoto Murakami
Bibliographic Information
Book Title: Bioactive Lipid Mediators
Book Subtitle: Current Reviews and Protocols
Editors: Takehiko Yokomizo, Makoto Murakami
DOI: https://doi.org/10.1007/978-4-431-55669-5
Publisher: Springer Tokyo
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s) 2015
Hardcover ISBN: 978-4-431-55668-8Published: 05 November 2015
Softcover ISBN: 978-4-431-56247-4Published: 23 August 2016
eBook ISBN: 978-4-431-55669-5Published: 27 October 2015
Edition Number: 1
Number of Pages: IX, 426
Topics: Lipidology, Cell Biology, Human Physiology