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Springer Theses

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

Authors: Inuki, Shinsuke

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  • Total synthesis of the bioactive natural products, pachastrissamine, lysergic acid, lysergol and isolysergol, by palladium-catalyzed domino cyclization of allenes and related compounds is investigated
  • Gives an insight to the development of efficient synthetic approaches for biologically active compounds
  • Nominated as an oustanding contribution by Kyoto University
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eBook 85,59 €
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  • ISBN 978-4-431-54043-4
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Hardcover 124,79 €
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Softcover 106,90 €
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About this book

The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Reviews

From the reviews:

“The target audience … includes practicing organic chemists with interests in synthesis, and those with specific interests in palladium-catalysed organic reactions, and as such is suited to graduate level and above. … is well-written and provides plenty of food for thought for specialists in palladium(II) chemistry … . the book also benefits from a comprehensive experimental section at the end of each chapter. … the book reflects the high quality experimental skills of the author, and provides a useful handbook for the synthetic organometallic chemist.” (Edward A. Anderson, Platinum Metals Review, Vol. 56 (3), 2012)


Table of contents (6 chapters)

Table of contents (6 chapters)

Buy this book

eBook 85,59 €
price for Spain (gross)
  • ISBN 978-4-431-54043-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 124,79 €
price for Spain (gross)
Softcover 106,90 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
Authors
Series Title
Springer Theses
Copyright
2012
Publisher
Springer Japan
Copyright Holder
Springer
eBook ISBN
978-4-431-54043-4
DOI
10.1007/978-4-431-54043-4
Hardcover ISBN
978-4-431-54042-7
Softcover ISBN
978-4-431-56110-1
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XVI, 106
Topics