Serotonin and Sleep: Molecular, Functional and Clinical Aspects

1. Front Matter

   Pages I-XXVIII

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2. Evolution of concepts

   1. Front Matter

      Pages 1-1

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   2. Changing concepts on the role of serotonin in the regulation of sleep and waking

      • Reidun Ursin

      Pages 3-21

3. The dorsal raphe nucleus and median raphe nucleus: organization and projections

   1. Front Matter

      Pages 23-23

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   2. Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus

      • Christopher A. Lowry, Andrew K. Evans, Paul J. Gasser, Matthew W. Hale, Daniel R. Staub, Anantha Shekhar

      Pages 25-67

   3. Efferent and afferent connections of the dorsal and median raphe nuclei in the rat

      • Robert P. Vertes, Stephanie B. Linley

      Pages 69-102

   4. Reciprocal connections between the suprachiasmatic nucleus and the midbrain raphe nuclei: A putative role in the circadian control of behavioral states

      • Samüel Deurveilher, Kazue Semba

      Pages 103-131

4. Serotonin receptors

   1. Front Matter

      Pages 133-133

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   2. Localization of 5-HT receptors in the mammalian cortex

      • Noemí Santana, Julián de Almeida, Guadalupe Mengod, Francesc Artigas

      Pages 135-153

   3. Molecular biology of 5-HT receptors

      • Jason Hannon, Daniel Hoyer

      Pages 155-182

5. Electrophysiology of serotonergic neurons and the regulation of serotonin release

   1. Front Matter

      Pages 183-183

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   2. Brain serotonergic neuronal activity in behaving cats

      • Barry L. Jacobs, Casimir A. Fornal

      Pages 185-204

   3. Electrophysiological studies on serotonergic neurons and sleep

      • Kazuya Sakai

      Pages 205-236

   4. Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons

      • Pierre-Hervé Luppi, Damien Gervasoni, Christelle Peyron, Lucienne Leger, Denise Salvert, Patrice Fort

      Pages 237-250

   5. Regulation of serotonin release by inhibitory and excitatory amino acids

      • Sidney B. Auerbach

      Pages 251-285

   6. Neurophysiological aspects of the regulation of serotonin neurons by the orexinergic system

      • Christopher M. Sinton

      Pages 287-304

6. Serotonin receptors and the regulation of behavioural state

   1. Front Matter

      Pages 305-305

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   2. Serotonin and dreaming

      • Edward F. Pace-Schott

      Pages 307-324

   3. Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking

      • Chiara M. Portas, Janne Grønli

      Pages 325-369

   4. Mechanisms involved in the inhibition of REM sleep by serotonin

      • Jaime M. Monti, Héctor Jantos

      Pages 371-385

Foreword Barry Jacobs once memorably commented that the problem in understanding the role of serotonin in the brain was that it was implicated in virtually eve- thing but responsible for nothing [1]. Serotonin (5-HT) is defnitely implicated in the regulation of sleep but what does it do? Once seen as a sleep-promoting molecule, Jacob’s own work, lucidly described in this volume, radically changed our view. In fact, serotonin neurons are most active during waking; their - tivity diminishes with sleep onset and disappears during rapid eye movement (REM) sleep. Serotonin, therefore, is intimately linked to the sleep-wake cycle, but what is its role, what mechanisms are involved and what are the impli- tions for sleep medicine and psychiatry? Making progress with these diffcult questions requires a “translational” approach, which is a research paradigm where both laboratory and clinical neuroscience inform and guide each other with the ultimate aim of improving understanding and treatment of medical conditions. This volume is a superb example of translational research, where leading basic and clinical scientists - tegrate molecular, neuropharmacological and systems approaches to illuminate the reciprocal interactions of serotonin neurons and the mechanisms involved in sleep and circadian regulation. Serotonin is an ancient chemical mediator preserved through at least 500 m- lion years of evolution. In invertebrate animals such as mollusks and leeches, 5-HT cells are distributed throughout the nervous system among the various ganglia.

• Arousal
• Nervous System
• biology
• brain
• central nervous system
• cortex
• evolution
• molecular biology
• neurons
• physiology
• protein
• psychopharmacology
• receptor
• regulation
• serotonin

• Pharmacology and Therapeutics, School of Medicine, Clinics Hospital, Montevideo, Uruguay

  Jaime M. Monti

• Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, USA

  S. R. Pandi-Perumal

• Green Hall, Program in Neuroscience, Princeton University, Princeton, USA

  Barry L. Jacobs

• Psychopharmacology Unit, Bristol, UK

  David J. Nutt

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