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Heat Shock Proteins and Inflammation

  • Book
  • © 2003

Overview

Editors:
  1. Willem Eden

    1. Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands

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  • Focuses on immunity to HSPs and the impact on the regulation of inflammation
  • Includes aspects of specific adaptive as well as innate immunity
  • Gives a basis for understanding the mode of action of HSP-based immunotherapeutic interventions
  • Provides data from experimental model systems as well as clinical research
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiii
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  2. HSP60 and the regulation of inflammation: Physiological and pathological

    • Irun R. Cohen, Francisco J. Quintana, Gabriel Nussbaum, Michal Cohen, Alexandra ZaninZhorov, Ofer Lider
    Pages 1-13

  3. Heat shock proteins and suppression of inflammation

    • Willem van Eden, Liesbeth Paul, Ruurd van der Zee
    Pages 15-31

  4. Heat shock proteins in immune response

    • Sreyashi Basu, Pramod Srivastava
    Pages 33-42

  5. Heat shock protein-mediated activation of innate immune cells

    • Clarissa U. I. Prazeres da Costa, Hermann Wagner, Thomas C. Miethke
    Pages 43-54

  6. Eukaryotic HSP60: A “danger signal” for T- and natural killer cells

    • Arne van Bonin, Minka Breloer, Solveig H. MorĂ©
    Pages 55-67

  7. Heat shock proteins and experimental arthritis

    • Rebecca J. Brownlie, Stephen J. Thompson
    Pages 69-82

  8. Heat shock proteins and reactive arthritis

    • J. S. Hill Gaston, Richard C. Duggleby, Jane C. Goodall, Roberto Raggiaschi, Mark S. Lillicrap
    Pages 83-96

  9. The development of immune therapy with HSP60 for juvenile idiopathic arthritis

    • IsmĂ© M. de Kleer, Berent P. Prakken, Salvatore Albani, Wietse Kuis
    Pages 97-108

  10. Heat shock proteins and rheumatoid arthritis

    • Gabriel S. Panayi, Valerie M. Corrigall
    Pages 109-137

  11. Heat shock proteins for immunotherapy of rheumatoid arthritis

    • Gisella L. Puga Yung, Tho D. Le, Sarah Roord, Berent Prakken, Salvatore Albani
    Pages 139-158

  12. Immunity to heat shock proteins and atherosclerosis

    • Michael Knoflach, Bruno Mayrl, Mahavir Singh, Georg Wick
    Pages 159-173

  13. Chaperonins: Chameleon proteins that influence myeloid cells

    • Brian Henderson
    Pages 175-192

  14. Heat shock protein receptors, functions and their effect on monocytes and dendritic cells

    • Thomas Lehner, Yufei Wang, Charles Kelly
    Pages 193-216

  15. Heat shock protein expression in transplanted kidney

    • Klemens Trieb
    Pages 217-231

  16. Mycobacterial heat shock proteins and the bovine immune system

    • Ad P Koets
    Pages 233-244

  17. Microbial infection generates pro-inflammatory autoimmunity against the small heat shock protein alpha B-crystallin and provides the fuel for the development of multiple sclerosis

    • Johannes M. van Noort
    Pages 245-256

  18. HSP60-peptide interference with CD94/NKG2 receptors

    • Kalle Söderström
    Pages 257-272

  19. Back Matter

    Pages 273-280
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Keywords

About this book

Heat shock proteins (HSP) have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection with inflammation was established when it was uncovered that T cells specific for these antigens have a crucial role in the induction and regulation of experimental arthritis. Since then, the raised presence of immunity to HSPs in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to HSPs in inflammatory diseases.

Editors and Affiliations

  • Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands

    Willem Eden

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