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Cell-Based Therapies in Stroke

  • Book
  • © 2013

Overview

Editors:
  1. Jukka Jolkkonen

    1. , Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

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  2. Piotr Walczak

    1. School of Medicine, Division of MR Research, Johns Hopkins University, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Gives a comprehensive account of cell-based treatment strategies for stroke
  • State-of-the-art contents
  • With contributions by international experts
  • Includes supplementary material: sn.pub/extras

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. Preclinical Optimization of Cell Therapies

    1. Front Matter

      Pages 1-1
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  3. Preclinical optimization of cell therapies

    1. Cell Therapy and Structural Plasticity Following Cerebral Ischemia

      • Stanley Hoang, Henry Jung, Tonya Bliss, Gary Steinberg
      Pages 3-14

    2. Delivery Routes for Cell Therapy in Stroke

      • Alison E. Willing, Md Shahaduzzaman
      Pages 15-28

    3. Different Sources of Stem Cells for Transplantation Therapy in Stroke

      • Travis Dailey, David J. Eve, Naoki Tajiri, Tsz Lau, Yusef Mosley, Harry van Loveren et al.
      Pages 29-46

    4. Efficacy of Transplant and Endogenous Precursor and Stem Cell Interventions on Stroke Recovery: A Critical Assessment

      • Dale Corbett, Cindi Morshead, Molly Shoichet
      Pages 47-61

  4. Translational Imaging Techniques to Study Cell Therapy

    1. Front Matter

      Pages 63-63
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  5. Translational imaging techniques to study cell therapy

    1. Cell Labeling Methods for Noninvasive MR Imaging of Stem Cells

      • Jeff W. M. Bulte
      Pages 65-74

    2. Strategies for Enhanced, MRI-Guided Targeting of Stem Cells to Stroke Lesions

      • Michael Gorelik, Piotr Walczak
      Pages 75-91

    3. Image-Guided Injection and Noninvasive Monitoring of Tissue Regeneration in the Stroke-Damaged Brain

      • Chung-Hsing Chou, Francesca Nicholls, Michel Modo
      Pages 93-104

    4. Tracking of Autologous VSOP-Labeled Mesenchymal Stem Cells in the Sheep Brain Using 3.0 T MRI

      • Antje Y. Dreyer, Donald Lobsien, Claudia Pösel, Karl-Titus Hoffmann, Björn Nitzsche, Matthias Findeisen et al.
      Pages 105-125

    5. Neural Stem Cell Mapping with High-Resolution Rapid-Scanning X-Ray Fluorescence Imaging

      • Angela M. Auriat, Helen Nichol, Michael Kelly, Raphael Guzman
      Pages 127-136

    6. In Vivo Biodistribution Studies and Cell Tracking in Stroke Using SPECT Imaging

      • Mari Raki, Kim Bergström, Jukka Jolkkonen
      Pages 137-149

  6. Early Phase Clinical Studies

    1. Front Matter

      Pages 151-151
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  7. Early phase clinical studies

    1. Clinical Trials: Intracerebral Cell Therapy in Stroke Patients

      • Douglas Kondziolka, Gillian Harrison, Lawrence Wechsler
      Pages 153-170

    2. Intravenous Cell Therapies for Stroke

      • Osman Mir, Aditya P. Lal, Farhaan Vahidy, Kaushik Parsha, Sean I. Savitz
      Pages 171-179

    3. Intra-arterial Cell Therapy in Stroke Patients

      • Gabriel R. de Freitas, Rosália Mendez-Otero
      Pages 181-190

    4. Intraventricular Route of Cell Transplantation for Stroke-Related Diseases: Rationale, Risk, and Early Clinical Experience

      • Miroslaw Janowski
      Pages 191-201

  8. Back Matter

    Pages 203-204
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Keywords

About this book

Stroke remains one of the main causes of death and disability worldwide. While effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.

Reviews

“This is one of the several very good monographs published by Springer concerning the molecular, cellular, and translational models on animal and clinical stroke. The role of stem cells (bone marrow, umbilical, neural precursors & mesenchymal) derived transplants are discussed in separate chapters. … The advantage of this book is it is very current discussing the most up to date journal data and analysis. This will guide active investigators with information guiding their animal and clinical research studies.” (Joseph J. Grenier, Amazon.com, June, 2016)

“This book reviews the methodology of cell-based therapy and discusses potential applications. … a valuable reference for researchers as well as clinicians who are interested in the evolving field of cell-based therapy. … This book provides a balanced approach to cell-based therapy. … The topics discussed here provide insight into the science of cell-based therapy. The information … is for the most part presented in a manner readily understood by those who are not experts in the field.” (Benjamin H. Eidelman, Doody’s Book Reviews, August, 2013)

Editors and Affiliations

  • , Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

    Jukka Jolkkonen

  • School of Medicine, Division of MR Research, Johns Hopkins University, Baltimore, USA

    Piotr Walczak

Bibliographic Information

  • Book Title: Cell-Based Therapies in Stroke

  • Editors: Jukka Jolkkonen, Piotr Walczak

  • DOI: https://doi.org/10.1007/978-3-7091-1175-8

  • Publisher: Springer Vienna

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Wien 2013

  • Hardcover ISBN: 978-3-7091-1174-1Published: 25 January 2013

  • Softcover ISBN: 978-3-7091-1696-8Published: 26 June 2015

  • eBook ISBN: 978-3-7091-1175-8Published: 30 January 2013

  • Edition Number: 1

  • Number of Pages: VIII, 204

  • Topics: Neurology, Imaging / Radiology, Neurosciences

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