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BestMasters

A Concise Semisynthesis of Hederagonic Acid

C–H Activation in Natural Product Synthesis

Authors: Knittl-Frank, Christian

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  • The shortest semisynthesis of this oleanane
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eBook 53,49 €
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  • ISBN 978-3-658-30011-1
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  • ISBN 978-3-658-30010-4
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About this book

Christian Knittl-Frank reports on the development of a novel synthetic route to the naturally occurring polyhydroxylated oleanane, hederagonic acid. Polyhydroxylated oleananes are a vast family of naturally occurring triterpenoids with versatile biological activities. A low commercial availability combined with high prices make these molecules interesting targets in natural product synthesis. The developed synthetic approach starts from oleanolic acid, a cheap material that is commercially available in bulk quantities. It features several multi-step one-pot reactions, allowing a minimization of the number of steps and reducing the preparative effort. Importantly, catalytic C–H functionalization was achieved at unusually low temperatures. Hederagonic acid was thus prepared in as little as four steps, resulting in the shortest semisynthesis of this oleanane to date.

The Author

Christian Knittl-Frank is currently pursuing his PhD studies, focusing on natural product synthesis and synthetic methodology, at the Department of Organic Chemistry, University of Vienna, Austria. He is part of the MolTag doctoral program that aims to development new molecular drugs targeting ion channels.

About the authors

Christian Knittl-Frank is currently pursuing his PhD studies, focusing on natural product synthesis and synthetic methodology, at the Department of Organic Chemistry, University of Vienna, Austria. He is part of the MolTag doctoral program that aims to development new molecular drugs targeting ion channels.

Table of contents (3 chapters)

Table of contents (3 chapters)

Buy this book

eBook 53,49 €
price for Spain (gross)
  • ISBN 978-3-658-30011-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 67,59 €
price for Spain (gross)
  • ISBN 978-3-658-30010-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
A Concise Semisynthesis of Hederagonic Acid
Book Subtitle
C–H Activation in Natural Product Synthesis
Authors
Series Title
BestMasters
Copyright
2020
Publisher
Springer Spektrum
Copyright Holder
The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wiesbaden GmbH, part of Springer Nature
eBook ISBN
978-3-658-30011-1
DOI
10.1007/978-3-658-30011-1
Softcover ISBN
978-3-658-30010-4
Series ISSN
2625-3577
Edition Number
1
Number of Pages
XIX, 60
Number of Illustrations
1 b/w illustrations
Topics

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