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Endocytosis

From Cell Biology to Health, Disease and Therapy

  • Conference proceedings
  • © 1992

Overview

Editors:
  1. Pierre J. Courtoy

    1. Cell Biology Unit, Louvain University Medical School and International Institute of Cellular and Molecular Pathology, Brussels, Belgium

Part of the book series: Nato ASI Subseries H: (ASIH, volume 62)

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About this book

(Director: Pierre J. COURTOY) Two years after its first gathering in Oeiras, Portugal, the European Endocytosis Group convened for a second workshop at the Pasteur Institute, Paris, on October 1-5, 1990. The meeting is reported in detail in this volume; a preliminary coverage, based on the overviews of each session, has appeared in the New Biologist (1991, 3:243-252). The three main objectives, to broaden the audience, to present a more comprehensive view of the multiple aspects of endocytosis, from basic biology to health, disease and therapy, as well as to clarify controversial issues, have been largely fulfilled. The Second European Workshop on Endocytosis was attended by more than tOO participants, originating from 18 countries. 59 lectures and 35 posters were presented. In addition, vivi~ roundtables allowed to thoroughly discuss the dynamics and the regulation of the endocytic apparatus, as well as the role of endocytosis in antigen presentation. Endocytosis is a general and distinctive property of all eukaryotic cells, including protists, plants and fungi.

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Table of contents (62 papers)

  1. Front Matter

    Pages I-XVIII
    Download chapter PDF

  2. Structure, Dynamics and Functions of the Endocytic Apparatus

    1. Front Matter

      Pages 1-2
      Download chapter PDF

    2. Surface Events: Mobility and Clustering

      1. Dynamic Cytomatrix-Membrane Interactions Investigated with Nanovid Microscopy
        • M. De Brabander, R. Nuydens, H. Geerts
        Pages 3-8
      2. Analysis of Receptor Dynamics, as Studied with Surface Replicas
        • Horst Robenek
        Pages 9-16
      3. Surface Distribution and Pathway of Internalization of C3b Receptors (CR1) in Human Neutrophils
        • J.-P. Paccaud, J.-L. Carpentier
        Pages 17-23

    3. Clathrin-Coated Pits and Clathrin-Independent Endocytosis

      1. The Dynamics of Clathrin Coats in Living Cells Measured by Advanced Fluorescence Microscopy
        • Jean Davoust, Pierre Cosson
        Pages 27-42
      2. Assembly Proteins and Adaptors in Clathrin Coated Vesicles
        • Ernst Ungewickell, Robert Lindner, Stephan Schröder
        Pages 43-50
      3. Molecular Biology of the Adaptins
        • Margaret S. Robinson
        Pages 51-56
      4. Clathrin-independent endocytosis
        • Bo van Deurs, Steen H. Hansen, Kirsten Sandvig
        Pages 57-62

    4. Dynamics of Endosomes

      1. New Insights into the Endocytic Pathway
        • Colin R. Hopkins, Karen M. Miller
        Pages 65-72
      2. The Compartments of the Endocytic Pathway
        • Gareth Griffiths
        Pages 73-83
      3. Protein Exchange Within the Lysosome and Pre-Lysosome Compartment: A Mechanism for Maintaining Organelle Functionality?
        • B. Storrie, Y. Deng
        Pages 85-90
      4. Endosomal pH Regulation and the Maturation Model for Lysosome Biogenesis
        • Robert F. Murphy, Mario Roederer, David M. Sipe, Cynthia Corley Cain, Russell B. Wilson
        Pages 91-95

    5. Cell-Free Analysis of Endocytic Traffic

      1. Effect of ATPγS on the Formation of Coated Vesicles in Broken Hela Cells
        • Marc Pypaert, Graham Warren
        Pages 99-104
      2. ATP is Required for Receptor-Mediated Endocytosis Both <i>in Vivo</i> and <i>in Vitro</i>
        • Sandra L. Schmid, Laura L. Carter, Elizabeth Smythe
        Pages 105-111
      3. Regulation of Endocytic Membrane Traffic
        • Jean Gruenberg, Jean-Pierre Gorvel, Morgane Bomsel
        Pages 113-121
      4. The Interaction of Late Endosomes with Lysosomes in a Cell-Free System
        • J. Paul Luzio, Barbara M. Mullock
        Pages 123-129
      5. Roundtable on Cell-Free Systems
        • Kathryn Howell
        Pages 131-132

    6. Molecular Processing by Endosomes

      1. Regulation of ATP-Dependent Endosome Acidification
        • R. Fuchs, S. Schmid, I. Mellman, H. Klapper
        Pages 135-140
      2. Degradation of Insulin and Glucagon in Isolated Liver Endosomes: Functional Relationships with ATP-Dependent Endosomal Acidification and Partial Characterization of Degradation Products
        • Bernard Desbuquois, François Authier, Jean-Pierre Clot, Michel Janicot, Françoise Fouque
        Pages 141-149
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Editors and Affiliations

  • Cell Biology Unit, Louvain University Medical School and International Institute of Cellular and Molecular Pathology, Brussels, Belgium

    Pierre J. Courtoy

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