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Secretin, Cholecystokinin, Pancreozymin and Gastrin

  • Book
  • © 1973

Overview

Authors:
  1. M. Bodanszky

    1. Dept. of Chemistry, Case Western Reserve University, Cleveland, USA

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  2. R. Carratù
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  3. D. A. Dreiling
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  4. R. Fussgänger
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  5. H. D. Janowitz
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  6. J. D. Jamieson

    1. The Rockefeller University, New York, USA

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  7. J. E. Jorpes

    1. Kemiska Institutionen II, Karolinska Institutet, Stockholm, Sweden

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  8. V. Mutt

    1. Kemiska Institutionen II, Karolinska Institutet, Stockholm, Sweden

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  9. E. F. Pfeiffer

    1. Zentrum für Innere Medizin und Kinderheilkunde, Ulm, Deutschland

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  10. J. Plessier

    1. Médecin Attaché de L’Hopital St.-Antoine, Paris VIIE, France

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  11. M. L. Ramorino
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  12. S. Raptis
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  13. A. Torsoli

    1. Divisone Gastroenterologica, II. Clinica Medica, Università, Roma, Italy

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  14. M. J. Zimmerman

    1. New York, USA

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Editors:
  1. J. E. Jorpes

    1. Kemiska Institutionen II, Karolinska Institutet, Stockholm, Sweden

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  2. V. Mutt

    1. Kemiska Institutionen II, Karolinska Institutet, Stockholm, Sweden

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 34)

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Table of contents (7 chapters)

  1. Front Matter

    Pages I-XII
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  2. Secretin and Cholecystokinin (CCK)

    • J. Erik Jorpes, Viktor Mutt
    Pages 1-179

  3. The Synthesis of (Porcine) Secretin

    • Miklos Bodanszky
    Pages 180-194

  4. The Secretory Process in the Pancreatic Exocrine Cell: Morphologic and Biochemical Aspects

    • James D. Jamieson
    Pages 195-217

  5. The Secretin Test

    • Maurice J. Zimmerman, David A. Dreiling, Henry D. Janowitz
    Pages 218-246

  6. On the Use of Cholecystokinin in the Roentgenological Examination of the Extrahepatic Biliary Tract and Intestines

    • A. Torsoli, M. L. Ramorino, R. Carratù
    Pages 247-258

  7. Gastrointestinal Hormones and Islet Function

    • E. F. Pfeiffer, S. Raptis, R. Fussgänger
    Pages 259-310

  8. The Use of Cholecystokinin in the Roentgenological Examination II. Clinical Aspects

    • Jacques Plessier
    Pages 311-343

  9. Back Matter

    Pages 345-376
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Keywords

About this book

In the beginning of this century physiology witnessed the creation of a new concept, the hormonal regulation of the work of the digestive organs. It was found that such essential functions as the flow of pancreatic juice and emptying of bile into the intestine were regulated by two hormones, secretin and cholecystokinin, respectively. Already in 1925 French authors attempted to measure the functional capacity of the exocrine pancreas by means of stimulation with secretin. The use­ fulness of the secretin test in this connection was definitely established by Scandinavian workers in the 1930's. In spite of the difficulties in obtaining secretin American authors succeeded in keeping the interest in the secretin test alive. The development in the 1950's of counter-current, ion exchange and chromato­ graphic techniques offered new possibilities in this field. The intestinal hormones were known to be relatively low molecular peptides and these could now be isolated in pure form. Thus secretin was isolated in 1961, and cholecystokinin in 1964. The newly developed methods for peptide analysis likewise soon brought us full information about the primary structure of the peptides. Gastrin, the specific stimulant of the gastric acid secretion, which was discovered in 1905 and acknowledged as a hormone in 1938, was the first of the gastrointestinal hormones for which the structure became known. This was in 1964. Synthesis soon followed. These developments are reviewed in the first chapter of the present volume.

Authors, Editors and Affiliations

  • Kemiska Institutionen II, Karolinska Institutet, Stockholm, Sweden

    J. E. Jorpes, V. Mutt, J. E. Jorpes, V. Mutt

  • Dept. of Chemistry, Case Western Reserve University, Cleveland, USA

    M. Bodanszky

  • The Rockefeller University, New York, USA

    J. D. Jamieson

  • Zentrum für Innere Medizin und Kinderheilkunde, Ulm, Deutschland

    E. F. Pfeiffer

  • Médecin Attaché de L’Hopital St.-Antoine, Paris VIIE, France

    J. Plessier

  • Divisone Gastroenterologica, II. Clinica Medica, Università, Roma, Italy

    A. Torsoli

  • New York, USA

    M. J. Zimmerman

Bibliographic Information

  • Book Title: Secretin, Cholecystokinin, Pancreozymin and Gastrin

  • Authors: M. Bodanszky, R. Carratù, D. A. Dreiling, R. Fussgänger, H. D. Janowitz, J. D. Jamieson, J. E. Jorpes, V. Mutt, E. F. Pfeiffer, J. Plessier, M. L. Ramorino, S. Raptis, A. Torsoli, … M. J. Zimmerman

  • Editors: J. E. Jorpes, V. Mutt

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-80704-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin · Heidelberg 1973

  • Softcover ISBN: 978-3-642-80706-0Published: 15 December 2011

  • eBook ISBN: 978-3-642-80704-6Published: 29 June 2013

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XII, 376

  • Topics: Medicine/Public Health, general, Pharmacy

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