Current Topics in Microbiology and Immunology

Transmissible Spongiform Encephalopathies:

Scrapie, BSE and Related Human Disorders

Editors: Chesebro, Bruce W. (Ed.)

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In spite of a long history of intense investigation the transmissible spongiform encephalopathies remain a poorly understood family of neurodegenerative diseases. This group of diseases has been described in a wide variety of animal species and includes kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler syndrome in humans, and scrapie, bovine spongiform encephalopathy, and related syndromes in ruminants and rodents. In all cases spongiform degeneration and astrocytosis are seen in specimens of brain and a filterable transmissible agent is present in the brain and some other tissues of affected individuals. However, the precise nature of this agent remains unknown. Agent infectivity, which can so far only be assayed by serial transmission to new individuals, be remarkably resistant to inactivation has been shown to by heat, chemicals, and irradiation. These properties create significant biohazard possibilities during exposure to infected tissues. Transmission between humans was originally reco­ gnized in the unique epidemiology of kuru in New Guinea tribesmen, and concern about transmission from animals to humans has re-emerged as a result of the current epidemic of bovine spongiform encephalopathy in dairy cattle in Great Britain. Although interspecies transmission has often been achieved experimentally, its efficiency is highly variable. There­ fore, the possibility of spread of bovine spongiform encephalopathy from cattle to humans or various animal populations cannot be accurately predicted at this time. This volume presents a comprehensive update of know­ ledge concerning the transmissible spongiform encephalo­ pathies.

Table of contents (16 chapters)

Table of contents (16 chapters)

Buy this book

eBook 106,99 €
price for Spain (gross)
  • ISBN 978-3-642-76540-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 135,19 €
price for Spain (gross)
  • ISBN 978-3-642-76542-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Transmissible Spongiform Encephalopathies:
Book Subtitle
Scrapie, BSE and Related Human Disorders
Editors
  • Bruce W. Chesebro
Series Title
Current Topics in Microbiology and Immunology
Series Volume
172
Copyright
1991
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-76540-7
DOI
10.1007/978-3-642-76540-7
Softcover ISBN
978-3-642-76542-1
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 288
Topics