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Neuronal Growth Factors

  • Book
  • © 1991

Overview

Editors:
  1. Mark Bothwell

    1. Department of Physiology and Biophysics, University of Washington, Seattle, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 165)

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Table of contents (7 chapters)

  1. Front Matter

    Pages I-IX
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  2. Structure and Biosynthesis of Nerve Growth Factor

    • M. Fahnestock
    Pages 1-26

  3. Biochemical Characterization of the Nerve Growth Factor Receptor in Neural-Related Tumors

    • A. H. Ross, G. Sobue, H. Hotta, U. R. Reddy
    Pages 27-38

  4. The Membrane Receptor for Nerve Growth Factor

    • M. V. Chao
    Pages 39-53

  5. Tissue Localization of Nerve Growth Factor and Nerve Growth Factor Receptors

    • M. Bothwell
    Pages 55-70

  6. Nerve Growth Factor Function in the Central Nervous System

    • F. H. Gage, M. H. Tuszynski, K. S. Chen, A. M. Fagan, G. A. Higgins
    Pages 71-93

  7. The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors

    • J. A. Wagner
    Pages 95-118

  8. Dissecting the Mode of Action of a Neuronal Growth Factor

    • S. Halegoua, R. C. Armstrong, N. E. Kremer
    Pages 119-170

  9. Back Matter

    Pages 171-176
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Keywords

About this book

A host of environmental factors regulate the embryonic development of neurons. In adults, the survival of neurons, the regeneration of damaged axons, and plastic changes in axonal arborization are also controlled by a complex array of environmental cues. An important category of regulatory influences involves target-derived hormone-like peptides act­ ing on neuronal cell surface receptors. Nerve growth factor (NGF) was the first such factor to be characterized (LEVI­ MONTALCINI and HAMBURGER 1953) and has served as the model against which all similar factors are compared. A number of factors with properties similar to NGF have been described with activities toward differing populations of neurons. Many of these factors have been characterized only poorly at the biochemical level. However, several factors have been charac­ terized to the extent that molecular clones are available and complete amino acid sequences are known. These include: three structurally related factors, NGF itself (SCOTT et al. 1983), brain-derived neurotrophic factor (BDNF) (LEIBROCK et al. 1989), and neurotrophin-3 (NT-3) (MAISONPIERRE et al. 1990; HOHN et al. 1990); ciliary neurotrophic factor (CNTF) (LIN et al. 1989) and a second set of structural homologs; acidic and basic fibroblast growth factors (aFGF, bFGF) (ABRAHAM et al. 1986; JAYE et al. 1986). Investigators have cloned the receptors for NGF (JOHNSON et al. 1986; RADEKE et al. 1987) and FGF (LEE et al. 1989).

Editors and Affiliations

  • Department of Physiology and Biophysics, University of Washington, Seattle, USA

    Mark Bothwell

Bibliographic Information

  • Book Title: Neuronal Growth Factors

  • Editors: Mark Bothwell

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-75747-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1991

  • Softcover ISBN: 978-3-642-75749-5Published: 13 December 2011

  • eBook ISBN: 978-3-642-75747-1Published: 29 June 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 173

  • Number of Illustrations: 7 b/w illustrations

  • Topics: Allergology, Immunology, Neurosciences, Cell Biology

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