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Organotitanium Reagents in Organic Synthesis

  • Book
  • © 1986

Overview

Authors:
  1. Manfred T. Reetz

    1. Fachbereich Chemie der Universität Marburg, Marburg, Germany

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Part of the book series: Reactivity and Structure: Concepts in Organic Chemistry (REACTIVITY, volume 24)

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Table of contents (8 chapters)

  1. Front Matter

    Pages I-X
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  2. Introduction

    • Manfred T. Reetz
    Pages 1-16

  3. Synthesis and Properties of Some Simple Organotitanium Compounds

    • Manfred T. Reetz
    Pages 17-74

  4. Chemoselectivity in Reactions of Organotitanium Reagents with Carbonyl Compounds

    • Manfred T. Reetz
    Pages 75-112

  5. Rates of Reactions

    • Manfred T. Reetz
    Pages 113-122

  6. Stereoselectivity in the Addition of Organotitanium Reagents to Carbonyl Compounds

    • Manfred T. Reetz
    Pages 123-193

  7. Michael Additions

    • Manfred T. Reetz
    Pages 194-198

  8. Substitution Reactions

    • Manfred T. Reetz
    Pages 199-222

  9. Wittig-type Methylenation of Carbonyl Compounds

    • Manfred T. Reetz
    Pages 223-229

  10. Back Matter

    Pages 231-236
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Keywords

About this book

Titanium has been used to perform many kinds of reactions in organic and inorganic chemistry. The present book is concerned primarily with a new development in titanium chemistry which is useful in organic synthesis. In 1979/80 it was discovered that the titanation of classical carbanions using C1TiX leads to species with reduced basicity and reactivity. This increases 3 chemo-, regio-and stereo selectivity in reactions with organic compounds such as aldehydes, ketones and alkyl halides. Many new examples have been reported in recent times. Since the nature of the ligand X at titanium can be widely varied, the electronic and steric nature of the reagents is easily controlled. This helps in predicting the stereochemical outcome of many of the C-C bond forming reactions, but the trial and error method is still necessary in other cases. One of the ultimate objectives of chemistry is to understand correlations between structure and reactivity. Although this goal has not been reached in the area of organotitanium chemistry, appreciable progress has been made. A great deal of physical and computational data of organotitanium compounds described in the current and older literature (e. g. , Ziegler-Natta type catalysts) has been reported by polymer, inorganic and theoretical chemists. It is summarized in Chapter 2 of this book, because some aspects are useful in understanding reactivity and selectivity of organo­ titanium compounds in organic synthesis as described in the chapters which follow.

Authors and Affiliations

  • Fachbereich Chemie der Universität Marburg, Marburg, Germany

    Manfred T. Reetz

Bibliographic Information

  • Book Title: Organotitanium Reagents in Organic Synthesis

  • Authors: Manfred T. Reetz

  • Series Title: Reactivity and Structure: Concepts in Organic Chemistry

  • DOI: https://doi.org/10.1007/978-3-642-70704-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1986

  • Softcover ISBN: 978-3-642-70706-3Published: 17 November 2011

  • eBook ISBN: 978-3-642-70704-9Published: 11 November 2013

  • Series ISSN: 0341-2377

  • Edition Number: 1

  • Number of Pages: X, 236

  • Topics: Organic Chemistry

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