Clinical Hepatology

1. Front Matter

   Pages I-X

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2. History of Hepatology

   • F. H. Franken

   Pages 1-15

3. Differential Diagnosis of Liver Diseases by Enzyme Patterns. A Historical Review

   • F. De Ritis, L. Cacciatore

   Pages 16-28

4. Functional Dissection of the Diseased Liver

   • R. Preisig

   Pages 29-44

5. Hepatic Drug Disposition in Liver Disease: Consequences for Dosage Adjustments

   • J. Bircher

   Pages 45-51

6. Biliary Lipids and Gallstone Formation

   • M. C. Carey

   Pages 52-69

7. Current Concepts on Bilirubin Metabolism and Gilbert’s Syndrome

   • L. Okolicsanyi

   Pages 70-77

8. Protein Synthesis

   • R. E. Kirsch

   Pages 78-86

9. The Position of Laparoscopy Among Methods Used in Differential Diagnosis of Chronic Liver Diseases

   • H. Henning

   Pages 87-100

10. The Role of the Gallbladder and the Sphincter of Oddi in the Regulation of Enterohepatic Bile Acid Circulation and Biliary Lipid Secretion

    • W. Kurtz, M. Classen

    Pages 101-111

11. Cultured Kupffer and Endothelial Cells from Human and Rat Livers — A New Means of Studying Viral Infections of the Liver

    • A. Kirn

    Pages 112-125

12. Liver Fibrosis: A Dynamic Process?

    • M. Rojkind, D. Kershenobich

    Pages 126-142

13. Liver Biopsy

    • H. Thaler

    Pages 143-158

14. Ultrastructural Pathology of the Human Liver

    • U. Pfeifer

    Pages 159-194

15. Immune Reactions in Liver Diseases

    • K.-H. Meyer zum Büschenfelde, T. H. Hütteroth, M. Manns

    Pages 195-209

16. Viral Hepatitis — An Update

    • W. Arnold, G. Hess, T. Poralla

    Pages 210-235

17. Vaccination Against Hepatitis B Virus: Past and Future Problems

    • J. Pillot

    Pages 236-243

18. Animal Models in Hepatitis Research

    • S. M. Lemon

    Pages 244-260

19. Present Status of Liver Transplantation

    • T. E. Starzl, S. Iwatsuki, B. W. Shaw Jr.

    Pages 261-267

20. New Approaches to the Management of Portal Hypertension and Variceal Haemorrhage

    • D. Westaby, B. Macdougall, R. Williams

    Pages 268-280

Hepatology has come of age in the last decades. Biology of the liver has flour­ ished long before. As the largest homogeneous organ of the body the liver served as useful model in the development of biochemistry and related discip­ lines. Only gradually were these biological investigations applied to the clinical study of liver disease. This was particularly stimulated by the recognition that in the greater part of the world, the developing countries and what we now call the Third World, liver disease represents a major threat to overall public health. It leads to morbidity and mortality of persons in their productive years from liver cancer, cirrhosis and parasitic disease, particularly, schistosomiasis. Moreover, the growing emphasis on the social impact of diseases focused on disorders of the liver because malnutrition, poverty, and drug addiction contrib­ ute greatly to their spread. This is compounded by the increase of alcohol abuse, recently on the rise even in the developing countries. Concern with envi­ ronmental pollution has also raised the interest in liver diseases, in part because the liver acts as a guardian against polluting chemicals and in part because it is considered, possibly to an exaggerated degree, a vulnerable target of such chemicals.

• Lebererkrankung
• cancer
• hepatology
• liver
• liver disease

• Department of Clinical Research, Germany

  Géza Csomós

• School of Medicine, University of Vienna, Austria

  Heribert Thaler

• Wilhelminenspital of the City of Vienna, Vienna, Austria

  Heribert Thaler

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