Overview
- Editors:
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Alan C. Sartorelli
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Department of Pharmacology, Yale University School of Medicine, New Haven, USA
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David G. Johns
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Laboratory of Chemical Pharmacology, National Cancer Institute, National Istitutes of Health, Bethesda, USA
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Table of contents (29 chapters)
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Front Matter
Pages I-XXIV
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General Considerations: Antineoplastic Agents
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- Abraham Goldin, Stephen Carter, Nathan Mantel
Pages 12-32
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- Leroy B. Townsend, C. C. Cheng
Pages 112-141
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- Elton Stubblefield, Sandra Murphree
Pages 194-204
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- Daniel S. Zaharko, Robert L. Dedrick
Pages 220-228
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- A. M. Guarino, C. L. Litterst
Pages 288-318
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- Alan L. Cowles, Joseph D. Fenstermacher
Pages 319-329
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About this book
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a. single volume the entire field of drugs emยญ ployed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories throughยญ out the world. At the molecular level, knowledge of the modes of action of estabยญ lished agents has continued to expand, and has permitted rational drug design to playa significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.
Editors and Affiliations
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Department of Pharmacology, Yale University School of Medicine, New Haven, USA
Alan C. Sartorelli
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Laboratory of Chemical Pharmacology, National Cancer Institute, National Istitutes of Health, Bethesda, USA
David G. Johns
