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Epigenetics and Human Health

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

Editors: Bonifer, Constanze, Cockerill, Peter (Eds.)

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  • Translational aspect: describes how immune cell function is controlled and highlights human diseases where this is dysfunctional
  • From animal models to humans: Describes how more primitive organisms use the epigenetic regulatory machinery and explains what controls the function of specialized cells of the human immune system
  • With extensive glossary
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eBook 118,99 €
price for Spain (gross)
  • ISBN 978-3-642-45198-0
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  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-3-642-45197-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,50 €
price for Spain (gross)
  • ISBN 978-3-662-51466-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.

Table of contents (15 chapters)

Table of contents (15 chapters)
  • The Epigenetic Regulatory Machinery

    Pages 1-11

    Bonifer, Constanze (et al.)

  • What Can We Learn from Flies: Epigenetic Mechanisms Regulating Blood Cell Development in Drosophila

    Pages 15-47

    Badenhorst, Paul

  • Epigenetic and Transcriptional Mechanisms Regulating Blood Cell Development in Zebrafish

    Pages 49-63

    Bai, Xiaoying

  • Epigenetic and Transcriptional Mechanisms Regulating the Development of the Haematopoietic System in Mammals

    Pages 67-93

    Fleury, Maud (et al.)

  • Polycomb Complexes: Chromatin Regulators Required for Cell Diversity and Tissue Homeostasis

    Pages 95-139

    Vidal, Miguel

Buy this book

eBook 118,99 €
price for Spain (gross)
  • ISBN 978-3-642-45198-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-3-642-45197-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,50 €
price for Spain (gross)
  • ISBN 978-3-662-51466-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
Editors
  • Constanze Bonifer
  • Peter Cockerill
Series Title
Epigenetics and Human Health
Copyright
2014
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-45198-0
DOI
10.1007/978-3-642-45198-0
Hardcover ISBN
978-3-642-45197-3
Softcover ISBN
978-3-662-51466-5
Series ISSN
2191-2262
Edition Number
1
Number of Pages
XIII, 416
Number of Illustrations
49 illustrations in colour
Topics