Transformative Concepts for Drug Design: Target Wrapping

Authors: Fernandez, Ariel

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  • Profound understanding of how to rationally design drugs.
  • Knowledge of innovative concepts in molecular design with translational and transformative applicability.
  • Development of new therapeutic agents to fight cancer.
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About this book

In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. This book squarely addresses this crucial problem since it introduces fundamental discoveries in basic biomolecular research that hold potential to broaden the technological base of the pharmaceutical industry. The book takes a fresh and fundamental look at the problem of how to design an effective drug with controlled specificity. Since the novel transformative concepts are unfamiliar to most practitioners, the first part of this book explains matters very carefully starting from a fairly elementary physico-chemical level. The second part of the book is devoted to practical applications, aiming at nothing less than a paradigm shift in drug design. This book is addressed to scientists working at the cutting edge of research in the pharmaceutical industry, but the material is at the same time accessible to senior undergraduates or graduate students interested in drug discovery and molecular design.

Reviews

From a News Release of the Rice University, Houston, Texas: "Drug Design: New book introduces fresh approach. Rice professor says drug industry can improve drug safety, lower costs. The pharmaceutical industry can reduce costs, bring new drugs to market more quickly and decrease the dangerous side effects of new medications if it pays closer attention to the latest research regarding the subtle differences between closely related protein targets. A new book, "Transformative Concepts for Drug Design: Target Wrapping" (Springer) by Rice University bioengineering professor Ariel Fernandez, suggests new methods the industry can use to improve its bottom line today. ... Fernandez said it takes about a decade and costs about $1 billion to bring a new drug to market, and the lead time and costs for drug development are increasing."

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy

    Fernandez, Prof. Dr. Ariel

    Pages 1-15

  • Wrapping Defects and the Architecture of Soluble Proteins

    Fernandez, Prof. Dr. Ariel

    Pages 17-26

  • Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins

    Fernandez, Prof. Dr. Ariel

    Pages 27-47

  • Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design

    Fernandez, Prof. Dr. Ariel

    Pages 49-58

  • Under-Wrapped Proteins in the Order–Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation

    Fernandez, Prof. Dr. Ariel

    Pages 59-78

Buy this book

eBook n/a
  • ISBN 978-3-642-11792-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-3-642-11791-6
  • Free shipping for individuals worldwide
Softcover n/a
  • ISBN 978-3-642-42458-8
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Transformative Concepts for Drug Design: Target Wrapping
Authors
Copyright
2010
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
Distribution Rights
Distribution rights for India: CBS Publishers, New Delhi, India
eBook ISBN
978-3-642-11792-3
DOI
10.1007/978-3-642-11792-3
Hardcover ISBN
978-3-642-11791-6
Softcover ISBN
978-3-642-42458-8
Edition Number
1
Number of Pages
X, 230
Topics