Editors:
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 190)
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Table of contents (20 chapters)
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Front Matter
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Aquaporin Protein Structure and Selectivity Mechanisms
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Aquaporin Function in Mammalian Water Homeostasis
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Aquaporin Glycerol Permeability in Mammalian Physiology
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Aquaporin Functions Apart from Water and Glycerol Transport
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Towards Therapeutic Use of Aquaporins
About this book
The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerable (and growing) number of aquaporin crystal structures for the rational design of inhibitory molecules, ii. elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments, iii. comprehensive data on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological studies, and v. assay systems for compound library screenings. The structure of this volume on aquaporins follows the points laid out above and thus covers the developments from basic research to potential pharmacological use. Situated between pharmacology textbooks and recent scientific papers this book provides a timely overview for readers from the fundamental as well as the applied disciplines.
Editors and Affiliations
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Pharmazeutisches Inst., Universität Kiel, Kiel, Germany
Eric Beitz
Bibliographic Information
Book Title: Aquaporins
Editors: Eric Beitz
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-540-79885-9
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2009
Hardcover ISBN: 978-3-540-79884-2Published: 19 December 2008
Softcover ISBN: 978-3-642-09866-6Published: 22 November 2010
eBook ISBN: 978-3-540-79885-9Published: 19 December 2008
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: XVI, 424
Number of Illustrations: 87 b/w illustrations, 6 illustrations in colour
Topics: Pharmacology/Toxicology, Human Physiology, Life Sciences, general, Nephrology, Neurology, Hematology