Advances in Anatomy, Embryology and Cell Biology

Neuroanatomy and Pathology of Sporadic Parkinson's Disease

Authors: Braak, Heiko, Del Tredici, Kelly

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About this book

The proteinopathy sporadic Parkinson’s disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer’s disease. The a -synuclein inclusion body pathology (Lewy pathology) associated with sPD is distributed throughout the central, peripheral, and enteric nervous systems. The resulting nonrandom neuronal dysfunction and, in some regions, neuronal loss is reflected by a distinctive topographic distribution pattern of the Lewy pathology that, in the brain, has been staged. Except for olfactory structures and spinal cord constituents of the pain system, sensory components of the nervous system remain uninvolved or virtually intact. The most disease-related damage revolves around motor areas – particularly around superordinate centers of the limbic and visceromotor systems as well as portions of the somatomotor system. Vulnerable regions are interconnected anatomically and susceptible nerve cell types are not neurotransmitter-dependent.

Not all clinical symptoms emerging in the course of sPD can be explained by a lack of dopamine in the nigrostriatal system. These include autonomic dysfunction, pain, hyp- or anosmia, excessive daytime sleepiness, REM sleep behavioral disorder, depression, anxiety, cognitive decline, and dementia. Against the background of the normal morphology and anatomy, the authors analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.

Table of contents (10 chapters)

Table of contents (10 chapters)

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-3-540-79850-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 145,59 €
price for Spain (gross)
  • ISBN 978-3-540-79849-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Neuroanatomy and Pathology of Sporadic Parkinson's Disease
Authors
Series Title
Advances in Anatomy, Embryology and Cell Biology
Series Volume
201
Copyright
2009
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-79850-7
DOI
10.1007/978-3-540-79850-7
Softcover ISBN
978-3-540-79849-1
Series ISSN
0301-5556
Edition Number
1
Number of Pages
VII, 119
Number of Illustrations
29 illustrations in colour
Topics