Research and Perspectives in Alzheimer's Disease

Synaptic Plasticity and the Mechanism of Alzheimer's Disease

Editors: Selkoe, Dennis J., Triller, Antoine (Eds.)

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  • ISBN 978-3-540-76330-7
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Hardcover 207,99 €
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  • ISBN 978-3-540-76329-1
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Softcover 207,99 €
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About this book

During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.

Table of contents (13 chapters)

Table of contents (13 chapters)

Buy this book

eBook 160,49 €
price for Spain (gross)
  • ISBN 978-3-540-76330-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 207,99 €
price for Spain (gross)
  • ISBN 978-3-540-76329-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 207,99 €
price for Spain (gross)
  • ISBN 978-3-642-09519-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Synaptic Plasticity and the Mechanism of Alzheimer's Disease
Editors
  • Dennis J. Selkoe
  • Antoine Triller
Series Title
Research and Perspectives in Alzheimer's Disease
Copyright
2008
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-76330-7
DOI
10.1007/978-3-540-76330-7
Hardcover ISBN
978-3-540-76329-1
Softcover ISBN
978-3-642-09519-1
Series ISSN
0945-6066
Edition Number
1
Number of Pages
XII, 183
Number of Illustrations
8 b/w illustrations, 26 illustrations in colour
Topics