Synaptic Plasticity and the Mechanism of Alzheimer's Disease
Editors: Selkoe, Dennis J., Triller, Antoine (Eds.)
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- About this book
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During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.
- Table of contents (13 chapters)
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Permanence of the Synapse and Molecular Instability
Pages 1-18
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Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity
Pages 19-35
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Imaging of Experience-Dependent Structural Plasticity in the Mouse Neocortex in vivo
Pages 37-49
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Synapse Loss, Synaptic Plasticity and the Postsynaptic Density
Pages 51-62
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Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity
Pages 63-68
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Table of contents (13 chapters)
- Download Preface 1 PDF (87.6 KB)
- Download Sample pages 1 PDF (303.8 KB)
- Download Table of contents PDF (91.2 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Synaptic Plasticity and the Mechanism of Alzheimer's Disease
- Editors
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- Dennis J. Selkoe
- Antoine Triller
- Series Title
- Research and Perspectives in Alzheimer's Disease
- Copyright
- 2008
- Publisher
- Springer-Verlag Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- eBook ISBN
- 978-3-540-76330-7
- DOI
- 10.1007/978-3-540-76330-7
- Hardcover ISBN
- 978-3-540-76329-1
- Softcover ISBN
- 978-3-642-09519-1
- Series ISSN
- 0945-6066
- Edition Number
- 1
- Number of Pages
- XII, 183
- Number of Illustrations
- 8 b/w illustrations, 26 illustrations in colour
- Topics
