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Non-Protein Coding RNAs

  • Book
  • © 2009

Overview

Editors:
  1. Nils G. Walter

    1. Department of Chemistry, University of Michigan, Ann Arbor, USA

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  2. Sarah A. Woodson

    1. Department of Biophysics, Johns Hopkins University, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Robert T. Batey

    1. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, USA

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  • Biophysical perspective on a rapidly expanding number of non-protein coding RNAs
  • Overview on how non-protein coding RNAs work and how biophysical techniques and other probing techniques help delineate the molecular underpinnings of RNA function
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Series in Biophysics (BIOPHYSICS, volume 13)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. RNA 3D Structural Motifs: Definition, Identification, Annotation, and Database Searching

    • Lorena Nasalean, Jesse Stombaugh, Craig L. Zirbel, Neocles B. Leontis
    Pages 1-26

  3. Theory of RNA Folding: From Hairpins to Ribozymes

    • D. Thirumalai, Changbong Hyeon
    Pages 27-47

  4. Thermodynamics and Kinetics of RNA Unfolding and Refolding

    • Pan T. X. Li, Ignacio Tinoco Jr.
    Pages 49-72

  5. Ribozyme Catalysis of Phosphodiester Bond Isomerization: The Hammerhead RNA and Its Relatives

    • William G. Scott
    Pages 73-102

  6. The Small Ribozymes: Common and Diverse Features Observed Through the FRET Lens

    • Nils G. Walter, Shiamalee Perumal
    Pages 103-127

  7. Structure and Mechanism of the glmS Ribozyme

    • Juliane K. Soukup, Garrett A. Soukup
    Pages 129-143

  8. Group I Ribozymes as a Paradigm for RNA Folding and Evolution

    • Sarah A. Woodson, Seema Chauhan
    Pages 145-166

  9. Group II Introns and Their Protein Collaborators

    • Amanda Solem, Nora Zingler, Anna Marie Pyle, Jennifer Li- Pook-Than
    Pages 167-182

  10. Understanding the Role of Metal Ions in RNA Folding and Function: Lessons from RNase P, a Ribonucleoprotein Enzyme

    • Michael E. Harris, Eric L. Christian
    Pages 183-213

  11. Beyond Crystallography: Investigating the Conformational Dynamics of the Purine Riboswitch

    • Colby D. Stoddard, Robert T. Batey
    Pages 215-228

  12. Ligand Binding and Conformational Changes in the Purine-Binding Riboswitch Aptamer Domains

    • Jonas Noeske, Janina Buck, Jens Wöhnert, Harald Schwalbe
    Pages 229-247

  13. The RNA–Protein Complexes of E. coli Hfq: Form and Function

    • Taewoo Lee, Andrew L. Feig
    Pages 249-271

  14. Assembly of the Human Signal Recognition Particle

    • Elena Menichelli, Kiyoshi Nagai
    Pages 273-284

  15. Forms and Functions of Telomerase RNA

    • Kathleen Collins
    Pages 285-301

  16. Ribosomal Dynamics: Intrinsic Instability of a Molecular Machine

    • Haixiao Gao, Jamie Le Barron, Joachim Frank
    Pages 303-316

  17. Biophysical Analyses of IRES RNAs from the Dicistroviridae: Linking Architecture to Function

    • Jeffrey S. Kief
    Pages 317-333

  18. Structure and Gene-Silencing Mechanisms of Small Noncoding RNAs

    • Chia-Ying Chu, Tariq M. Rana
    Pages 335-356

  19. Back Matter

    Pages 357-398
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Keywords

About this book

The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, Andrew Fire and Craig Mello. This prize, which follows “RNA” Nobels for splicing and RNA catalysis, highlights just one class of recently discovered non-protein coding RNAs. Remarkably, non-coding RNAs are thought to outnumber protein coding genes in mammals by perhaps as much as four-fold. In fact, it appears that the complexity of an organism correlates with the fraction of its genome devoted to non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic tra- posons, higher-level organization of eukaryotic chromosomes, and gene expression are found to be largely directed by non-protein coding RNAs. Currently, bioinformatic, high-throughput sequencing, and biochemical approaches are identifying an increasing number of these RNAs. Unfortunately, our ability to characterize the molecular details of these RNAs is significantly lacking. The biophysical study of these RNAs is an emergent field that is unraveling the molecular underpinnings of how RNA fulfills its multitude of roles in sustaining cellular life. The resulting understanding of the physical and chemical processes at the molecular level is critical to our ability to harness RNA for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry.

Editors and Affiliations

  • Department of Chemistry, University of Michigan, Ann Arbor, USA

    Nils G. Walter

  • Department of Biophysics, Johns Hopkins University, Baltimore, USA

    Sarah A. Woodson

  • Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, USA

    Robert T. Batey

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