Current Topics in Microbiology and Immunology

The Interface Between Innate and Acquired Immunity

Editors: Cooper, M.D., Koprowski, H. (Eds.)

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About this book

All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mechanisms. A large array of naturally produced antimicrobial peptides has been de­ fined. A variety of cell surface receptors that recognize common patterns displayed by infectious organisms have been identified along with the intracellular pathways that these receptors use to activate cellular defense functions. Cell surface receptors on natural killer (NK) cells have been shown to sense microbial invasion in neighboring cells, thereby setting into motion their elimination by cy­ totoxic mechanisms. Other receptors have been found to facilitate phagocytosis and intracellular killing of microbes by phagocytic cells. These and other natural defense mechanisms have traditionally been viewed as the first line of body defense in vertebrate species that also possess the capacity for acquired or adaptive immunity. Sharks and all of the other jawed vertebrates generate large repertoires of T and B lymphocyte clones that display different antigen­ specific receptors in the form ofT cell receptors (TCR) and immunoglobulins (Ig) that allow them to recognize and respond to antigens in collaboration with antigen-present­ ing cells. Memory T and B cells are then generated to allow faster and heightened cellular and humoral immune re­ sponses on secondary antigen encounter. In recent years it has also become obvious that innate immune responses can directly influence adaptive immune responses in ways that will enhance body defense.

Table of contents (7 chapters)

  • The Relationship of Inflammation and Initiation of Autoimmune Disease: Role of TNF Super Family Members

    Flavell, R. A.

    Pages 1-9

    Preview Buy Chapter 30,19 €
  • Surface Receptors that Regulate the NK Cell Function: Beyond the NK Cell Scope

    Moretta, L. (et al.)

    Pages 11-22

    Preview Buy Chapter 30,19 €
  • Checkpoints in the Regulation of T Helper 1 Responses

    Heath, V. L. (et al.)

    Pages 23-39

    Preview Buy Chapter 30,19 €
  • The Role of Complement in Innate and Adaptive Immunity

    Volanakis, J. E.

    Pages 41-56

    Preview Buy Chapter 30,19 €
  • Several MHC-Linked Ig Superfamily Genes Have Features of Ancestral Antigen-Specific Receptor Genes

    Pasquier, L.

    Pages 57-71

    Preview Buy Chapter 30,19 €

Buy this book

eBook 107,09 €
price for Spain (gross)
  • ISBN 978-3-662-04700-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-3-540-42894-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 136,06 €
price for Spain (gross)
  • ISBN 978-3-642-07682-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
The Interface Between Innate and Acquired Immunity
Editors
  • M.D. Cooper
  • H. Koprowski
Series Title
Current Topics in Microbiology and Immunology
Series Volume
266
Copyright
2002
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-662-04700-2
DOI
10.1007/978-3-662-04700-2
Hardcover ISBN
978-3-540-42894-7
Softcover ISBN
978-3-642-07682-4
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIII, 118
Topics