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Topics in Current Genetics

Fine-Tuning of RNA Functions by Modification and Editing

Editors: Grosjean, Henri (Ed.)

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About this book

Naturally occurring RNA always contains numerous biochemically altered nucleotides. They are formed by enzymatic modification of the primary transcripts during the complex RNA maturation process designated RNA modification. A large number of enzymes catalyzing the formation of these modified nucleosides or converting one canonical base into another at the posttranscriptional level have been studied for many years, but only recently have systematic and comparative studies begun. The functions of individual enzymes and/or the modified/edited nucleosides in RNA, however, have remained largely ignored.

This book provides advance information on RNA modification, including the associated editing machinery, while offering the reader some perspective on the significance of such modifications in fine-tuning the structure and functions of mature RNA molecules and hence the ability to influence the efficiency and accuracy of genetic expression. Outstanding scientists who are actively working on RNA modification/editing processes have provided up-to-date information on these intriguing cellular processes that have been generated over the course of millions of years in all living organisms. Each review has been written and illustrated for a large audience of readers, not only specialists in the field, but also for advanced students or researchers who want to learn more about recent progress in RNA modification and editing.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Modification and editing of RNA: historical overview and important facts to remember

    Pages 1-22

    Grosjean, Henri

  • Biosynthesis and function of tRNA wobble modifications

    Pages 23-69

    Suzuki, Tsutomu

  • Editing and modification in trypanosomatids: the reshaping of non-coding RNAs

    Pages 71-86

    Rubio, Mary Anne T. (et al.)

  • Transfer RNA modifications and modifying enzymes in Saccharomyces cerevisiae

    Pages 87-120

    Johansson, Marcus J.O. (et al.)

  • Biosynthesis and function of 1-methyladenosine in transfer RNA

    Pages 121-139

    Anderson, James T. (et al.)

Buy this book

eBook 255,73 €
price for Spain (gross)
  • The eBook version of this title will be available soon
  • ISBN 978-3-540-31454-7
  • Digitally watermarked, DRM-free
  • Included format:
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  • Immediate eBook download after purchase
Hardcover 343,19 €
price for Spain (gross)
  • ISBN 978-3-540-24495-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 320,74 €
price for Spain (gross)
  • ISBN 978-3-642-06381-7
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Fine-Tuning of RNA Functions by Modification and Editing
Editors
  • Henri Grosjean
Series Title
Topics in Current Genetics
Series Volume
12
Copyright
2005
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-31454-7
DOI
10.1007/b95147
Hardcover ISBN
978-3-540-24495-0
Softcover ISBN
978-3-642-06381-7
Series ISSN
1610-2096
Edition Number
1
Number of Pages
XXIV, 442
Topics

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