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Handbook of Experimental Pharmacology

Cannabinoids

Editors: Pertwee, Roger G. (Ed.)

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  • ISBN 978-3-540-26573-3
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About this book

Less than 20 years ago the ?eld of cannabis and the cannabinoids was still c- sidered a minor, somewhat quaint, area of research. A few groups were active in the ?eld, but it was already being viewed as stagnating. The chemistry of cannabis 9 9 was well known, ? -tetrahydrocannabinol (? -THC), identi?ed in 1964, being the only major psychoactive constituent and cannabidiol, which is not psychoactive, possibly contributing to some of the effects. These cannabinoids and several s- thetic analogs had been thoroughly investigated for their pharmacological effects. Their mode of action was considered to be non-speci?c. The reasons for this - sumption were both technical and conceptual. On the technical side, it had been shown that THC was active in both enantiomeric forms (though with a different level of potency) and this observation was incompatible with action on biological substrates—a receptor, an enzyme, an ion channel—which react with a single stereoisomer only. The conceptual problem related to THC activity. This had been pointed out by several highly regarded research groups that had shown that many of the effects seen with cannabinoids were related to those of biologically active lipophiles, and that many of the effects of THC, particularly chronic ones, were comparable to those seen with anaesthetics and solvents.

Table of contents (25 chapters)

Table of contents (25 chapters)
  • Pharmacological Actions of Cannabinoids

    Pages 1-51

    Pertwee, R. G.

  • Cannabinoid Receptor Signaling

    Pages 53-79

    Howlett, A. C.

  • Molecular Biology of Cannabinoid Receptors

    Pages 81-115

    Abood, M. E.

  • Analysis of the Endocannabinoid System by Using CB1 Cannabinoid Receptor Knockout Mice

    Pages 117-145

    Valverde, O. (et al.)

  • The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids

    Pages 147-185

    Marzo, V. (et al.)

Buy this book

eBook 510,51 €
price for Spain (gross)
  • ISBN 978-3-540-26573-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 623,99 €
price for Spain (gross)
  • ISBN 978-3-540-22565-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Cannabinoids
Editors
  • Roger G. Pertwee
Series Title
Handbook of Experimental Pharmacology
Series Volume
168
Copyright
2005
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-26573-3
DOI
10.1007/b137831
Hardcover ISBN
978-3-540-22565-2
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XII, 772
Number of Illustrations
84 b/w illustrations, 3 illustrations in colour
Topics