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Current Topics in Microbiology and Immunology

Coronavirus Replication and Reverse Genetics

Editors: Enjuanes, Luis (Ed.)

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About this book

Coronaviruses are the RNA viruses with the largest genome known to date (27 to 32 kb). Members of this virus family affect most domestic animal species, causing important socio-economical losses, and also infect humans. Human coronaviruses were known to cause the winter common cold, a mild infection without important pathological consequences except in immuno-compromised patients. Recently, two new human coronaviruses have emerged, one causing the Severe and Acute Respiratory Syndrome (SARS) that infected more than 8000 individuals, leading to more than 800 deaths in 32 countries. This epidemic mobilized the World Health Organization, which launched travel restrictions to certain parts of the world for the first time in the last 50 years. The fact that coronaviruses, as many other viruses, crossed the species barrier to infect humans has posed a serious challenge to scientists involved in animal and human health. Control of coronavirus-induced diseases can only be the consequence of research on virus molecular biology and pathogenesis. This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Coronavirus Genome Structure and Replication

    Pages 1-30

    Brian, D. A. (et al.)

  • Coronavirus Transcription: A Perspective

    Pages 31-55

    Sawicki, S. G. (et al.)

  • The Coronavirus Replicase

    Pages 57-94

    Ziebuhr, J.

  • Viral and Cellular Proteins Involved in Coronavirus Replication

    Pages 95-131

    Shi, S. T. (et al.)

  • Coronavirus Reverse Genetics by Targeted RNA Recombination

    Pages 133-159

    Masters, P. S. (et al.)

Buy this book

eBook 149,79 €
price for Spain (gross)
  • ISBN 978-3-540-26765-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 187,19 €
price for Spain (gross)
  • ISBN 978-3-540-21494-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 187,19 €
price for Spain (gross)
  • ISBN 978-3-642-05997-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Coronavirus Replication and Reverse Genetics
Editors
  • Luis Enjuanes
Series Title
Current Topics in Microbiology and Immunology
Series Volume
287
Copyright
2005
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-540-26765-2
DOI
10.1007/b138038
Hardcover ISBN
978-3-540-21494-6
Softcover ISBN
978-3-642-05997-1
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XI, 257
Number of Illustrations
31 b/w illustrations, 18 illustrations in colour
Topics

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