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Biological and Medical Physics, Biomedical Engineering

Mathematical Modeling of Protein Complexes

Authors: Koshlan, Tatiana, Kulikov, Kirill

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  • Applies computational methods to simulate the electrostatic interaction of protein molecules to form complexes and domains
  • Predicts amino acid sequences with specific physical properties
  • Helps to improve the efficiency of experiments
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  • ISBN 978-3-319-98304-2
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Hardcover 135,19 €
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Softcover 135,19 €
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  • ISBN 978-3-030-07481-4
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About this book

This book is devoted to the physical and mathematical modeling of the formation of complexes of protein molecules. The models developed show remarkable sensitivity to the amino acid sequences of proteins, which facilitates experimental studies and allows one to reduce the associated costs by reducing the number of measurements required according to the developed criteria. These models make it possible to reach a conclusion about the interactions between different amino acid chains and to identify more stable sites on proteins.  The models also take the phosphorylation of amino acid residues into account.
At the end of the book, the authors present possible directions of application of their physical and mathematical models in clinical medicine.


About the authors

Tatiana Koshlan graduated from St. Petersburg State University, the department of Molecular Biophysics and Physics of Polymers. She is Master of Science in the field of biophysics. Now she is a post-graduate student at the department of Photonics, St. Petersburg State University. Her interdisciplinary research is in the field of biological and physical sciences. Her research is devoted to studying the interaction of biological molecules by physical methods, using mathematical tools to develop new technology and software with the ability to perform systematic measurements of various data sets of biological interactions.

Kirill Kulikov has been a full professor since 2014 at Peter the Great St. Petersburg Polytechnical University, Institute of Applied Mathematics and Mechanics, Department of Higher Mathematics. He received his Ph.D. in Physics and Mathematics with «Mathematical Modeling of the Optical Properties of Multilayer Biological Systems and Structures in their Heterogeneous Conjugation» (2004). He has habilitation at the State Polytechnical University (Great St. Petersburg Polytechnical University) of St. Petersburg, Russia (Doctor Science in Physics and Mathematics). His Doctor of Science thesis title was «Analytical models of interaction of laser radiation with complex heterogeneous biological tissues» (2014). His research interests are theory diffraction theory, electrodynamics, physics of lasers, tissue optical methods of mathematical modeling in biological tissue optics and numerical method, biophysics. 

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Physical Methods for Studying Proteins

    Pages 1-12

    Koshlan, Tatiana (et al.)

  • Mathematical Simulation of Complex Formation of Protein Molecules Allowing for Their Domain Structure

    Pages 13-54

    Koshlan, Tatiana (et al.)

  • Mathematical Modelling of the Temperature Effect on the Character of Linking Between Monomeric Proteins in Aqueous Solutions

    Pages 55-131

    Koshlan, Tatiana (et al.)

  • Mathematical Modelling of the Effect of a Monovalent Salt Solution on the Interaction of Protein Molecules

    Pages 133-168

    Koshlan, Tatiana (et al.)

  • Mathematical Modeling Identification of Active Sites Interaction of Protein Molecules

    Pages 169-262

    Koshlan, Tatiana (et al.)

Buy this book

eBook 106,99 €
price for Spain (gross)
  • ISBN 978-3-319-98304-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 135,19 €
price for Spain (gross)
  • ISBN 978-3-319-98303-5
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 135,19 €
price for Spain (gross)
  • ISBN 978-3-030-07481-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Mathematical Modeling of Protein Complexes
Authors
Series Title
Biological and Medical Physics, Biomedical Engineering
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-319-98304-2
DOI
10.1007/978-3-319-98304-2
Hardcover ISBN
978-3-319-98303-5
Softcover ISBN
978-3-030-07481-4
Series ISSN
1618-7210
Edition Number
1
Number of Pages
XIV, 367
Number of Illustrations
17 b/w illustrations, 48 illustrations in colour
Topics

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