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Endocytosis and Signaling

  • Book
  • © 2018

Overview

Editors:
  1. Christophe Lamaze

    1. Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, CNRS UMR3666, INSERM U1143, Institut Curie—Centre de Recherche, PSL Research University, Paris, France

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  2. Ian Prior

    1. Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Focuses on new findings regarding the context dependency of cell signaling
  • Shows that endocytosis provides an opportunity for modulating signaling networks’ output
  • Provides an overview of the latest scientific insights on the role of endocytic trafficking and subcellular location in modulation

Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 57)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Endosomal Network: Mediators and Regulators of Endosome Maturation

    • Maria Podinovskaia, Anne Spang
    Pages 1-38

  3. Integration of the Endocytic System into the Network of Cellular Functions

    • Noga Budick-Harmelin, Marta Miaczynska
    Pages 39-63

  4. GTPases Rac1 and Ras Signaling from Endosomes

    • Francesc Tebar, Carlos Enrich, Carles Rentero, Thomas Grewal
    Pages 65-105

  5. ESCRT and Membrane Protein Ubiquitination

    • Simona M. Migliano, David Teis
    Pages 107-135

  6. Retromer and Its Role in Regulating Signaling at Endosomes

    • Matthew N. J. Seaman
    Pages 137-149

  7. The Lysosome and Intracellular Signalling

    • Geoffrey G. Hesketh, Lena Wartosch, Luther J. Davis, Nicholas A. Bright, J. Paul Luzio
    Pages 151-180

  8. Interplay of Endocytosis and Growth Factor Receptor Signalling

    • Rachel Moore, Marta Giralt Pujol, Zhou Zhu, Elizabeth Smythe
    Pages 181-202

  9. Role of the Endocytosis of Caveolae in Intracellular Signaling and Metabolism

    • Olivia Muriel, Miguel Sánchez-Álvarez, Raffaele Strippoli, Miguel Angel del Pozo
    Pages 203-234

  10. EGFR Trafficking in Physiology and Cancer

    • Giusi Caldieri, Maria Grazia Malabarba, Pier Paolo Di Fiore, Sara Sigismund
    Pages 235-272

  11. Evolving View of Membrane Trafficking and Signaling Systems for G Protein-Coupled Receptors

    • Silvia Sposini, Aylin C. Hanyaloglu
    Pages 273-299

  12. Endosomal Trafficking During Mitosis and Notch-Dependent Asymmetric Division

    • Alicia Daeden, Marcos Gonzalez-Gaitan
    Pages 301-329
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Keywords

About this book

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. 

In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.  



Editors and Affiliations

  • Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, CNRS UMR3666, INSERM U1143, Institut Curie—Centre de Recherche, PSL Research University, Paris, France

    Christophe Lamaze

  • Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

    Ian Prior

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