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Delta Opioid Receptor Pharmacology and Therapeutic Applications

  • Book
  • © 2018

Overview

Editors:
  1. Emily M. Jutkiewicz

    1. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, USA

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  • Discusses emerging knowledge about the biological function of the delta opioid receptor
  • Describes therapeutic potential of the delta opioid receptor system
  • Describes unique trafficking and signaling properties of the delta opioid receptor

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 247)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-viii
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  2. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept

    • Akiyoshi Saitoh, Hiroshi Nagase
    Pages 3-19

  3. Multifunctional Opioid Ligands

    • Jessica P. Anand, Deanna Montgomery
    Pages 21-51

  4. Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins

    • Bernard P. Roques
    Pages 53-70

  5. Ligand-Directed Signaling at the Delta Opioid Receptor

    • Ana Vicente-Sanchez, Amynah A. Pradhan
    Pages 73-85

  6. Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons

    • Amaury François, Grégory Scherrer
    Pages 87-114

  7. Evidence and Function Relevance of Native DOR–MOR Heteromers

    • Catherine M. Cahill, Edmund Ong
    Pages 115-127

  8. OPRD1 Genetic Variation and Human Disease

    • Richard C. Crist, Toni-Kim Clarke
    Pages 131-145

  9. The Delta Opioid Receptor in Pain Control

    • Khaled Abdallah, Louis Gendron
    Pages 147-177

  10. Delta Opioid Receptors and Modulation of Mood and Emotion

    • Isaac J. Dripps, Emily M. Jutkiewicz
    Pages 179-197

  11. Delta Opioid Pharmacology in Relation to Alcohol Behaviors

    • Doungkamol Alongkronrusmee, Terrance Chiang, Richard M. van Rijn
    Pages 199-225

  12. Delta Opioid Receptors: Learning and Motivation

    • L. P. Pellissier, C. N. Pujol, J. A. J. Becker, J. Le Merrer
    Pages 227-260

  13. Delta Opioid Pharmacology in Parkinson’s Disease

    • Omar S. Mabrouk
    Pages 261-275

  14. Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders

    • M. Grant Liska, Marci G. Crowley, Trenton Lippert, Sydney Corey, Cesar V. Borlongan
    Pages 277-299

  15. Delta Opioid Receptors and Cardioprotection

    • Louise See Hoe, Hemal H. Patel, Jason N. Peart
    Pages 301-334

  16. The Roles of Opioid Receptors in Cutaneous Wound Healing

    • Mei Bigliardi-Qi, Paul Bigliardi
    Pages 335-345

  17. Correction to: Delta Opioid Receptor Pharmacology and Therapeutic Applications

    • Emily M. Jutkiewicz
    Pages C1-C2
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Keywords

About this book

This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.

Editors and Affiliations

  • Department of Pharmacology, University of Michigan Medical School, Ann Arbor, USA

    Emily M. Jutkiewicz

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