Systems Biology
Editors: Rajewsky, Nikolaus, Jurga, Stefan, Barciszewski, Jan (Eds.)
Free Preview- Presents a wide spectrum of topics from fundamentals of modelling networks, to image-driven systems biology and personalized medicineCombines fundamentals with clinical and agricultural applicationsWith a special topic on epigenetics in agriculture
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- About this book
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Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems.
Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described.
The chapter “Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses” is available open access under a CC BY 4.0 license via link.springer.com.
- About the authors
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Prof. Dr. Nikolaus Rajewsky,Berlin Inst. for Medical Systems Biology, MaxDelbrückCenter for Molecular Medicine,Berlin-Buch,Germanyrajewsky@mdc-berlin.de
Prof. Dr. Stefan Jurga, Adam Mickiewicz University, Nanobiomedical Center,Poznań,Polandstjurga@amu.edu.pl
Prof. Dr. Jan Barciszewski, Polish Academy of Sciences,Institute of Bioorganic Chemistry,Poznań,Polandjan.barciszewski@ibch.poznan.pl
- Table of contents (19 chapters)
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Systems Biology of Genome Structure and Dynamics
Pages 1-15
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A Systems Perspective of Complex Diseases: From Reductionism to Integration
Pages 17-36
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Systems Biology of Bacterial Immune Systems: Regulation of Restriction-Modification and CRISPR-Cas Systems
Pages 37-58
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Systems Biology of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis
Pages 59-75
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Systems Approaches to Map In Vivo RNA–Protein Interactions in Arabidopsis thaliana
Pages 77-95
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Table of contents (19 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Systems Biology
- Editors
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- Nikolaus Rajewsky
- Stefan Jurga
- Jan Barciszewski
- Series Title
- RNA Technologies
- Copyright
- 2018
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer International Publishing AG, part of Springer Nature
- eBook ISBN
- 978-3-319-92967-5
- DOI
- 10.1007/978-3-319-92967-5
- Hardcover ISBN
- 978-3-319-92966-8
- Softcover ISBN
- 978-3-030-06559-1
- Series ISSN
- 2197-9731
- Edition Number
- 1
- Number of Pages
- X, 401
- Number of Illustrations
- 14 b/w illustrations, 46 illustrations in colour
- Topics
*immediately available upon purchase as print book shipments may be delayed due to the COVID-19 crisis. ebook access is temporary and does not include ownership of the ebook. Only valid for books with an ebook version. Springer Reference Works and instructor copies are not included.
