Overview
- Extensive coverage of the roles played by inflammasomes in various diseases
- Examines the inflammasome as a potential therapeutic target
- Discusses pharmacological developments in inflammasome inhibition
Part of the book series: Experientia Supplementum (EXS, volume 108)
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Table of contents (15 chapters)
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Front Matter
Keywords
About this book
The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts.
Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.Editors and Affiliations
About the editors
Elísabet Alcocer-Gómez is Research Associate at the University of Sevilla. Her scientific interest is the implication of inflammasome complexes in psychiatric diseases and the effect of psychiatric drugs on the inhibition or induction of inflammasome activation.
Bibliographic Information
Book Title: Inflammasomes: Clinical and Therapeutic Implications
Editors: Mario D. Cordero, Elísabet Alcocer-Gómez
Series Title: Experientia Supplementum
DOI: https://doi.org/10.1007/978-3-319-89390-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-89389-1Published: 17 September 2018
Softcover ISBN: 978-3-030-07758-7Published: 03 January 2019
eBook ISBN: 978-3-319-89390-7Published: 04 September 2018
Series ISSN: 1664-431X
Series E-ISSN: 2504-3692
Edition Number: 1
Number of Pages: VIII, 400
Number of Illustrations: 37 b/w illustrations, 26 illustrations in colour
Topics: Molecular Medicine, Medical Biochemistry