Stromal Immunology

1. Front Matter

   Pages i-xiii

   PDF

2. Leukocyte-Stromal Interactions Within Lymph Nodes

   • Joshua D’Rozario, David Roberts, Muath Suliman, Konstantin Knoblich, Anne Fletcher

   Pages 1-22

3. Stromal Cell Responses in Infection

   • Paul M. Kaye

   Pages 23-36

4. Fibroblasts and Osteoblasts in Inflammation and Bone Damage

   • Jason D. Turner, Amy J. Naylor, Christopher Buckley, Andrew Filer, Paul-Peter Tak

   Pages 37-54

5. Molecular and Cellular Requirements for the Assembly of Tertiary Lymphoid Structures

   • C. G. Mueller, S. Nayar, J. Campos, F. Barone

   Pages 55-72

6. Mesenchymal Stem Cells as Endogenous Regulators of Inflammation

   • Hafsa Munir, Lewis S. C. Ward, Helen M. McGettrick

   Pages 73-98

7. Stromal Cells in the Tumor Microenvironment

   • Alice E. Denton, Edward W. Roberts, Douglas T. Fearon

   Pages 99-114

8. Immunosuppression by Intestinal Stromal Cells

   • Iryna V. Pinchuk, Don W. Powell

   Pages 115-129

9. Novel Models to Study Stromal Cell-Leukocyte Interactions in Health and Disease

   • Mattias Svensson, Puran Chen

   Pages 131-146

10. Back Matter

    Pages 147-151

    PDF

Research into and interest in the role of stromal cells in immunology has exploded over the past 15 years. The conventional view that placed non-hematopoietic stromal cells as passive, structural, and supportive entities has now been replaced with an appreciation that these cells have active, dynamic roles during immune responses, and thus impact on the pathophysiology of multiple immune-mediated diseases. This book serves to provide solid grounding in the fundamentals of stromal immunology, focusing on the biological aspects of their function in addition to highlighting key areas for the development of the field in the future. The book is also a unique source of information on emerging concepts that place stromal cells from outside lymphoid organs as major contributors to the biology of diverse conditions, such as rheumatoid arthritis, chronic parasitic infection, inflammatory bowel disease, and cancer.

• Cell Biology
• Immunotherapy
• Inflammation
• Stroma
• Stromal Cells
• immunology

• Somerville College, University of Oxford, Oxford, UK

  Benjamin M.J Owens

• F-star Biotechnology Ltd., Cambridge, UK

  Matthew A. Lakins

Dr. Benjamin Owens is Head of Business Development at EUSA Pharma and an RF Lecturer in Medicine at Somerville College, University of Oxford. His prior academic research programmes focused on the role of intestinal stromal cells in human chronic intestinal inflammation. In addition to his role in Industry, he teaches stromal immunology to final year medical students.


Dr. Matthew Lakins is a Senior Scientist at F-star Biotechnology Ltd. in Cambridge, UK. Prior to this he was an MRC Career Development Fellow at the MRC Cancer Unit at the University of Cambridge. Here his research interests lay at the interface of tumor-associated stromal biology and immunology, ultimately working toward understanding and exploiting the ability of the tumor microenvironment to manipulate host tumor immunogenicity.



Together, Dr. Owens and Dr. Lakins founded the BSI Stromal Immunology affinity group in 2010 and have since organized two internationalmeetings in York  and Cambridge.

Policies and ethics