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Hereditary Colorectal Cancer

Genetic Basis and Clinical Implications

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  • © 2018

Overview

Editors:
  1. Laura Valle

    1. Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de Llobregat, Barcelona, Spain

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  2. Stephen B. Gruber

    1. University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, USA

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  3. Gabriel Capellá

    1. Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de Llobregat, Barcelona, Spain

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  • Comprehensive and updated coverage of the topic

  • Novel findings and challenges discussed

  • Provides coverage of issues ranging from genetics to clinical description of the syndromes

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-x
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  2. Genetic Causes and Associated Phenotypes: Hereditary Nonpolyposis CRC

    1. Front Matter

      Pages 1-1
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    2. Lynch Syndrome

      • Elena M. Stoffel, Matthew B. Yurgelun, C. Richard Boland
      Pages 3-19

    3. The Molecular Basis of Lynch-like Syndrome

      • Gardenia Vargas-Parra, Matilde Navarro, Marta Pineda, Gabriel Capellá
      Pages 21-41

    4. Constitutional Mismatch Repair Deficiency

      • Chrystelle Colas, Laurence Brugières, Katharina Wimmer
      Pages 43-54

    5. Mismatch Repair-Proficient Hereditary Nonpolyposis Colorectal Cancer

      • Laura Valle
      Pages 55-66

    6. Genetic and Environmental Modifiers of Cancer Risk in Lynch Syndrome

      • Aung K. Win, Rodney J. Scott
      Pages 67-89

  3. Genetic Causes and Associated Phenotypes: Gastrointestinal Polyposis Syndromes

    1. Front Matter

      Pages 91-91
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    2. Adenomatous Polyposis Syndromes: Introduction

      • Stefan Aretz
      Pages 93-98

    3. Familial Adenomatous Polyposis or APC-Associated Polyposis

      • Maartje Nielsen, Stephan Aretz
      Pages 99-111

    4. Adenomatous Polyposis Syndromes: Polymerase Proofreading-Associated Polyposis

      • Claire Palles, Andrew Latchford, Laura Valle
      Pages 113-134

    5. Adenomatous Polyposis Syndromes: MUTYH-Associated Polyposis

      • Maartje Nielsen, Stephan Aretz
      Pages 135-148

    6. Adenomatous Polyposis Syndromes: NTHL1-Associated Polyposis / Tumor Syndrome

      • Maartje Nielsen, Stephan Aretz
      Pages 149-153

    7. Adenomatous Polyposis Syndromes: Germline Biallelic Inactivation of Mismatch Repair Genes

      • Stefan Aretz, Maartje Nielsen
      Pages 155-159

    8. Adenomatous Polyposis Syndromes: Unexplained Colorectal Adenomatous Polyposis

      • Stefan Aretz, Maartje Nielsen
      Pages 161-164

    9. Hamartomatous Polyposis Syndromes

      • Joanne Ngeow, Eliza Courtney, Kiat Hon Lim, Charis Eng
      Pages 165-183

    10. Hereditary Mixed Polyposis Syndrome

      • Huw Thomas, Ian Tomlinson
      Pages 185-192

    11. Serrated Polyposis Syndrome

      • Sabela Carballal, Francesc Balaguer, Antoni Castells
      Pages 193-205

  4. Genetic Diagnostics and Clinical Management

    1. Front Matter

      Pages 207-207
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    2. Genetic Testing in Hereditary Colorectal Cancer

      • Conxi Lázaro, Lidia Feliubadaló, Jesús del Valle
      Pages 209-232
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Keywords

About this book

This book provides information on a wide variety of  issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed.  

This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in,  hereditary cancer.  The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

Reviews

“This unique book is designed as a consultative source for individuals involved in the care of patients with colorectal cancer and patients at risk due to familial genetic testing. … Genetics counselors, medical geneticists, surgeons, and oncology specialists would find this book extremely useful. … One of the most impressive features of this book is the very useful abstract at the beginning of every chapter. … At the end, there is a section of registries and databases, extremely useful tools.” (Luis F. Escobar, Doody's Book Reviews, October, 2018)​

Editors and Affiliations

  • Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL and CIBERONC, Hospitalet de Llobregat, Barcelona, Spain

    Laura Valle, Gabriel Capellá

  • University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, USA

    Stephen B. Gruber

About the editors

Laura Valle, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Av. Gran Via 199-203, 08908
Barcelona, Spain
Prof. Dr. Stephen Gruber, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, 90033, USA
Dr. Gabriel Capella, Institut Català d'Oncologia (ICO), Av. de la Granvia de l'Hospitalet 199, 08907 Barcelona, Spain

Bibliographic Information

  • Book Title: Hereditary Colorectal Cancer

  • Book Subtitle: Genetic Basis and Clinical Implications

  • Editors: Laura Valle, Stephen B. Gruber, Gabriel Capellá

  • DOI: https://doi.org/10.1007/978-3-319-74259-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-74258-8Published: 18 May 2018

  • Softcover ISBN: 978-3-030-08948-1Published: 26 January 2019

  • eBook ISBN: 978-3-319-74259-5Published: 04 May 2018

  • Edition Number: 1

  • Number of Pages: X, 505

  • Number of Illustrations: 14 b/w illustrations, 39 illustrations in colour

  • Topics: Gene Function, Oncology, Cancer Research

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