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Engineering and Application of Pluripotent Stem Cells

  • Book
  • © 2018

Overview

Editors:
  1. Ulrich Martin

    1. Leibniz Research Labs for Biotechnology, Hannover Medical School (MHH), Hannover, Germany

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  2. Robert Zweigerdt

    1. Leibniz Research Labs for Biotechnology, Hannover Medical School (MHH), Hannover, Germany

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  3. Ina Gruh

    1. Leibniz Research Labs for Biotechnology, Hannover Medical School (MHH), Hannover, Germany

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  • Presents different bioengineering strategies applied to pluripotent stem cells
  • Explores the (re)programming to pluripotency
  • Reviews the use of pluripotent stem cells for tissue engineering and drug screening

Part of the book series: Advances in Biochemical Engineering/Biotechnology (ABE, volume 163)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-vii
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  2. Nonintegrating Human Somatic Cell Reprogramming Methods

    • Thorsten M. Schlaeger
    Pages 1-21

  3. Scalable Expansion of Pluripotent Stem Cells

    • Neta Lavon, Michal Zimerman, Joseph Itskovitz-Eldor
    Pages 23-37

  4. Scalable Cardiac Differentiation of Pluripotent Stem Cells Using Specific Growth Factors and Small Molecules

    • Henning Kempf, Robert Zweigerdt
    Pages 39-69

  5. Specific Cell (Re-)Programming: Approaches and Perspectives

    • Frauke Hausburg, Julia Jeannine Jung, Robert David
    Pages 71-115

  6. Bioengineered Cardiac Tissue Based on Human Stem Cells for Clinical Application

    • Monica Jara Avaca, Ina Gruh
    Pages 117-146

  7. Human Pluripotent Stem Cells to Engineer Blood Vessels

    • Xin Yi Chan, Morgan B. Elliott, Bria Macklin, Sharon Gerecht
    Pages 147-168

  8. Targeted Gene Editing in Human Pluripotent Stem Cells Using Site-Specific Nucleases

    • Sylvia Merkert, Ulrich Martin
    Pages 169-186

  9. Acquired Genetic and Epigenetic Variation in Human Pluripotent Stem Cells

    • O. Kyriakides, J. A. Halliwell, P. W. Andrews
    Pages 187-206

  10. Requirements for Using iPSC-Based Cell Models for Assay Development in Drug Discovery

    • Klaus Christensen, Filip Roudnicky, Christoph Patsch, Mark Burcin
    Pages 207-220

  11. Back Matter

    Pages 221-228
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Keywords

About this book

​This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening.

This book will appeal to researchers working in regenerative medicine and drug discovery, and to bioengineers and professionals interested in stem cell research.

Editors and Affiliations

  • Leibniz Research Labs for Biotechnology, Hannover Medical School (MHH), Hannover, Germany

    Ulrich Martin, Robert Zweigerdt, Ina Gruh

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