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  • © 2018

Neurodegenerative Diseases

Clinical Aspects, Molecular Genetics and Biomarkers

  • Includes four new chapters on recent developments

  • Translational (from bench to bedside) approach

  • Covers neurodegeneration in classically non-degenerative disorders

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-x
  2. Genetic Complexity of Early-Onset Alzheimer’s Disease

    • Mahdi Ghani, Christiane Reitz, Peter St George-Hyslop, Ekaterina Rogaeva
    Pages 29-50
  3. Genetic Risk Factors for Complex Forms of Alzheimer’s Disease

    • Céline Bellenguez, Jean-Charles Lambert
    Pages 51-76
  4. Risk Factors and Prevention in Alzheimer’s Disease and Dementia

    • Giulia Grande, Davide L. Vetrano, Francesca Mangialasche
    Pages 93-112
  5. Diagnosis of Frontotemporal Dementia

    • Giorgio Giulio Fumagalli
    Pages 113-121
  6. Genetic Risk Factors for Sporadic Frontotemporal Dementia

    • Raffaele Ferrari, Claudia Manzoni, Parastoo Momeni
    Pages 147-186
  7. Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models

    • Lars M. Ittner, Wei S. Lee, Kristie Stefanoska, Prita R. Asih, Yazi D. Ke
    Pages 187-219
  8. Fluid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia

    • Niklas Mattsson, Sotirios Grigoriou, Henrik Zetterberg
    Pages 221-252
  9. Genotypic and Phenotypic Heterogeneity in Amyotrophic Lateral Sclerosis

    • Nicola Ticozzi, Vincenzo Silani
    Pages 279-295
  10. Lewy Body Dementia

    • L. Bonanni, R. Franciotti, S. Delli Pizzi, A. Thomas, M. Onofrj
    Pages 297-312
  11. Rare Dementias

    • Camilla Ferrari, Benedetta Nacmias, Sandro Sorbi
    Pages 313-336
  12. Parkinson’s Disease: Contemporary Concepts and Clinical Management

    • Vanessa Carvalho, Carlota Vicente Cunha, João Massano
    Pages 349-378
  13. Neurodegeneration and Multiple Sclerosis

    • Axel Petzold
    Pages 379-400
  14. Back Matter

    Pages 401-407

About this book

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson’s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.

Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Editors and Affiliations

  • University of Milan, Fondazione Ca’ Granda, IRCCS Ospedale Policlinico, Milan, Italy

    Daniela Galimberti, Elio Scarpini

About the editors

Dr. Galimberti is the Secretary of the Dementia Panel of the European Academy of Neurology and the Italian Society for the research on dementia (Sindem).

She is author of more than 250 scientific articles in international peer-reviewed journals, 10 chapters in international volumes, and more than 350 contributions to conferences. She serves as reviewer for several neurological journals. She is a Senior Associate Editor of the “Journal of Alzheimer’s disease”.

Elio Scarpini got his degree in Neurology in 1981 and he is professor of Neurology at the University of Milan. He is the Chief of the Alzheimer Center at the Policlinico University Hospital (Milan, Italy). His main interests include clinical and therapeutic aspects of neurodegenerative disorders (Alzheimer’s disease, Frontotemporal Lobar Degeneration) and demyelinating diseases (Multiple Sclerosis).

He is author of more than 300 scientific articles in international peer-reviewed journals and serves as reviewer for several neurological journals.

 

Bibliographic Information

  • Book Title: Neurodegenerative Diseases

  • Book Subtitle: Clinical Aspects, Molecular Genetics and Biomarkers

  • Editors: Daniela Galimberti, Elio Scarpini

  • DOI: https://doi.org/10.1007/978-3-319-72938-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-72937-4Published: 03 April 2018

  • Softcover ISBN: 978-3-030-10289-0Published: 25 January 2019

  • eBook ISBN: 978-3-319-72938-1Published: 15 March 2018

  • Edition Number: 2

  • Number of Pages: X, 407

  • Number of Illustrations: 3 b/w illustrations, 20 illustrations in colour

  • Topics: Neurology, Neurosciences, Human Genetics

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access