Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs

1. Front Matter

   Pages i-xii

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2. From Endometriosis to Cancer: Spotlight on Intracellular Signaling Cascades and MicroRNAs

   • Talha Abdul Halim, Rukset Attar, Cristina Donfrancesco, Ammad Ahmad Farooqi, Farrukh Zaman

   Pages 1-10

3. Tyrosine Kinases, microRNAs, Epigenetics: New Insights in the Mechanisms of Leukemogenesis

   • Maria Ciccone, George A. Calin

   Pages 11-25

4. The Emerging Role of Exosomes in Cancer Progression and Their Potential as Therapy Targets

   • Carolina F. Ruivo, Sónia A. Melo

   Pages 27-45

5. Tranquilizing and Awakening ATM to Promote Killing of Cancer Cells

   • Yi Chieh Lim, Shahzad Bhatti, Ammad Ahmad Farooqi

   Pages 47-58

6. The Role of GPER Signaling in Carcinogenesis: A Focus on Prostate Cancer

   • Marília I. Figueira, Henrique J. Cardoso, Sílvia Socorro

   Pages 59-117

7. Bone Cancer: Dysregulation of Signaling Cascades by microRNAs

   • Janaina de Andréa Dernowsek

   Pages 119-128

8. The Roles of miR-25 and Its Targeted Genes in Human Cancer

   • Carmen Caiazza, Palmiro Poltronieri, Massimo Mallardo

   Pages 129-139

9. Notch Signaling in Lung Cancer Initiation and Development

   • Kayla C. Lewis, Yi Liu

   Pages 141-149

10. TGF-β/Smad Signalling Pathway in Cancer

    • Mohadeseh Hasanpourghadi, Mohd. Rais Mustafa

    Pages 151-185

11. Natural Agents Mediated Regulation of microRNAs: Do We Need Skilled Archers to Hit the Bullseye

    • Eun Jung Sohn, Ammad Ahmad Farooqi, Hwan Tae Park

    Pages 187-197

12. Sebaceous Carcinoma of the Eyelid

    • Armando Luis Garcia, Ke Jin, Ravi Doddapaneni, Catherine Jeeyun Choi, Maria Paula Fernandez, Sander Dubovy et al.

    Pages 199-220

13. Current Knowledge of miRNAs as Biomarkers in Breast Cancer

    • Maria Luisa Gasparri, Zein Mersini Besharat, Aris Raad Besharat, Ilary Ruscito, Konstantinos Nirgianakis, Ammad Ahmad Farooqi et al.

    Pages 221-231

14. Signaling Landscape of AML: The Story So Far

    • Chiara Martinelli

    Pages 233-262

15. When the Molecules Start Playing Chess, or How MicroRNAs Acquire Dualistic Activity During Cancer Progression

    • Krassimira Todorova, Soren Hayrabedyan

    Pages 263-277

16. The Crosstalk Between miRNAs and Autophagy in Cancer Progression

    • Bayraktar Oznur, Gozuacik Devrim

    Pages 279-291

17. Role of CEACAM in Different Cancers

    • Ilhan Yaylim, Ghazala Butt, Sumbul Khalid, Ammad Ahmad Farooqi

    Pages 293-300

18. Back Matter

    Pages 301-308

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Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics.


This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.

• Signaling Cascades
• Molecular Oncology
• Cancer Development and Progression
• Signal Transduction
• microRNA

• Department of Biochemistry, Rashid Latif Medical College (RLMC), Lahore, Pakistan

  Sundas Fayyaz

• Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

  Ammad Ahmad Farooqi

Sundas Fayyaz is working as a Scientist in research laboratory of Rashid Latif Medical College (RLMC). Her expertise lies in cancer genetics and therapeutics. 


Ammad Ahmad Farooqi is currently a Senior Scientist at the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad, Pakistan. His area of research is tightly focused on cancer genetics and therapeutics.

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