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Bacterial Pathogens and Their Virulence Factors

  • Book
  • © 2018

Overview

Authors:
  1. Douglas I. Johnson

    1. Department of Microbiology & Molecular Genetics, University of Vermont, Burlington, USA

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  • Detailed description of 32 major bacterial pathogens that affect human health and their associated virulence determinants
  • Provides in-depth descriptions of the individual virulence factors involved in pathogenecity
  • All information is derived from primary literature and review articles
  • Includes supplementary material: sn.pub/extras

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-xv
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  2. Bacterial Virulence Factors

    • Douglas I. Johnson
    Pages 1-38

  3. Gram-Positive Bacterial Pathogens

    1. Front Matter

      Pages 39-39
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    2. Bacillus spp.

      • Douglas I. Johnson
      Pages 41-50

    3. Clostridium spp.

      • Douglas I. Johnson
      Pages 51-71

    4. Corynebacterium spp.

      • Douglas I. Johnson
      Pages 73-79

    5. Enterococcus spp.

      • Douglas I. Johnson
      Pages 81-91

    6. Listeria spp.

      • Douglas I. Johnson
      Pages 93-102

    7. Mycobacterium spp.

      • Douglas I. Johnson
      Pages 103-119

    8. Propionibacterium spp.

      • Douglas I. Johnson
      Pages 121-125

    9. Staphylococcus spp.

      • Douglas I. Johnson
      Pages 127-149

    10. Streptococcus spp.

      • Douglas I. Johnson
      Pages 151-174

  4. Gram-Negative Bacterial Pathogens

    1. Front Matter

      Pages 175-175
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    2. Bacteroides spp.

      • Douglas I. Johnson
      Pages 177-182

    3. Bordetella spp.

      • Douglas I. Johnson
      Pages 183-190

    4. Borrelia spp.

      • Douglas I. Johnson
      Pages 191-197

    5. Campylobacter spp.

      • Douglas I. Johnson
      Pages 199-207

    6. Escherichia spp.

      • Douglas I. Johnson
      Pages 209-239

    7. Francisella spp.

      • Douglas I. Johnson
      Pages 241-247

    8. Haemophilus spp.

      • Douglas I. Johnson
      Pages 249-256
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Keywords

About this book

Bacterial Pathogens and their Virulence Factors contains a detailed description of 32 major bacterial pathogens that affect human health and their associated virulence determinants. Chapter 1 gives an overview of the different types and classes of general virulence factors involved in host cell adherence and invasion, dissemination within the host, host cell damage, and evasion of host defense systems, as well as mechanisms by which these virulence factors are regulated. Chapters 2 through 33 give concise descriptions of the disease states associated with the 32 bacterial genera and their major pathogenic species, along with an in-depth description of the individual virulence factors that have been found to be functionally involved in pathogenicity.  A detailed bibliography derived from primary literature and review articles accompanies each of these chapters, allowing the reader to delve more deeply into individual pathogens and their virulence determinants. Chapter 34 discusses the exciting possibilities and initial successes of using detailed information on a pathogen’s virulence toolkit to design new therapeutics aimed at specific virulence traits.

Authors and Affiliations

  • Department of Microbiology & Molecular Genetics, University of Vermont, Burlington, USA

    Douglas I. Johnson

About the author

Dr. Johnson received his B.S. degree in Chemistry from Miami University in 1978 and his Ph.D. in Biochemistry from Purdue University in 1983.  His doctoral research with Dr. Ronald Somerville focused on the isolation of new mutants that affected transcriptional regulation of amino acid biosynthesis in E. coli.  Post-doctoral work with Dr. John Pringle at the University of Michigan centered on control of the yeast Saccharomyces cerevisiae cell cycle, with the initial discovery of the Cdc42 GTPase and its role in regulating the actin cytoskeleton.  Dr. Johnson’s research in the Department of Microbiology and Molecular Genetics at the University of Vermont extended the analysis of Cdc42 in S. cerevisiae, Schizosaccharomyces pombe, and the pathogenic yeast Candida albicans.  In addition, anti-virulence studies with small molecule inhibitors of the budded-to-hyphal transition virulence determinant in C. albicans were undertaken.  Dr. Johnson’s primary teaching responsibilities are introductory Microbiology and Infectious Disease and advanced Clinical Microbiology, which provided the impetus for writing this book.

Bibliographic Information

  • Book Title: Bacterial Pathogens and Their Virulence Factors

  • Authors: Douglas I. Johnson

  • DOI: https://doi.org/10.1007/978-3-319-67651-7

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2018

  • Hardcover ISBN: 978-3-319-67650-0Published: 08 December 2017

  • Softcover ISBN: 978-3-319-88460-8Published: 22 June 2018

  • eBook ISBN: 978-3-319-67651-7Published: 23 November 2017

  • Edition Number: 1

  • Number of Pages: XV, 461

  • Number of Illustrations: 16 b/w illustrations, 114 illustrations in colour

  • Topics: Infectious Diseases, Bacteriology, Medical Microbiology

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